Strategies for Controlling Afucosylation in Monoclonal Antibodies during Upstream Manufacturing.
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DOI: 10.1002/biot.202200604
Abstract: Core fucosylation is a highly prevalent and significant feature of N-glycosylation in therapeutic monoclonal antibodies produced by mammalian cells where its absence (afucosylation) plays a key role in treatment safety and efficacy. Notably, even slight… read more here.
Keywords: afucosylation; upstream manufacturing; strategies controlling; controlling afucosylation ... See more keywords
Interaction of cell culture process parameters for modulating mAb afucosylation
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DOI: 10.1002/bit.26908
Abstract: The extent of afucosylation, which refers to the absence of core fucose on Fc glycans, can correlate positively with the antibody‐dependent cellular cytotoxicity (ADCC) activity of a monoclonal antibody (mAb). Therefore, it is important to… read more here.
Keywords: cell culture; culture; culture process; afucosylation ... See more keywords