Conventional molecular dynamics and metadynamics simulation studies of the binding and unbinding mechanism of TTR stabilizers AG10 and tafamidis.
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DOI: 10.1021/acschemneuro.0c00338
Abstract: Amyloid transthyretin (ATTR) amyloidosis is a widespread and fatal systemic amyloidosis characterized by the misfolding and amyloid aggregation of Transthyretin (TTR). Studies suggest that dissociation of the TTR tetramer is the key step for its… read more here.
Keywords: molecular dynamics; ag10 tafamidis; ttr; conventional molecular ... See more keywords