Inhibition of Akt and other AGC kinases: A target for clinical cancer therapy?
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2017.04.011
Abstract: AGC kinases have been identified to contribute to cancer development and progression. Currently, most AGC inhibitors in clinical development are Akt inhibitors such as MK-2206 or GDC-0068, which are known to promote cell growth arrest… read more here.
Keywords: inhibition akt; agc kinases; akt inhibitors; clinical development ... See more keywords
Uncoupling TORC2 from AGC kinases inhibits tumour growth
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20086
Abstract: Mammalian target of rapamycin (mTOR) is a central regulator of growth and metabolism. mTOR resides in two distinct multi-protein complexes – mTORC1 and mTORC2 – with distinct upstream regulators and downstream targets. While it is… read more here.
Keywords: agc kinases; tumour growth; mtor; growth ... See more keywords