Analysis of Epigenetic Age Acceleration and Healthy Longevity Among Older US Women
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.23285
Abstract: This cohort study investigates the association of epigenetic age acceleration with odds of surviving to age 90 with intact function among older US women. read more here.
Keywords: among older; epigenetic age; older women; age ... See more keywords
Association between depression and epigenetic age acceleration: A co‐twin control study
Sign Up to like & getrecommendations! Published in 2022 at "Depression and Anxiety"
DOI: 10.1002/da.23279
Abstract: Prior studies have shown inconsistent findings of an association between depression and epigenetic aging. DNA methylation (DNAm) age acceleration can measure biological aging. We adopted a robust co‐twin control study design to examine whether depression… read more here.
Keywords: association depression; depression; depression epigenetic; age acceleration ... See more keywords
Grip strength is inversely associated with DNA methylation age acceleration
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13110
Abstract: There is a large body of evidence linking muscular weakness, as determined by low grip strength, to a host of negative ageing‐related health outcomes. Given these links, grip strength has been labelled a ‘biomarker of… read more here.
Keywords: strength; dna methylation; age acceleration; grip strength ... See more keywords
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume.
Sign Up to like & getrecommendations! Published in 2022 at "GeroScience"
DOI: 10.1007/s11357-022-00558-8
Abstract: The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to age-related disorders, such as Alzheimer's Disease (AD). Whilst studies have reported associations with AD… read more here.
Keywords: hippocampal volume; age acceleration; age; epigenetic clocks ... See more keywords
Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging
Sign Up to like & getrecommendations! Published in 2021 at "Biological psychiatry"
DOI: 10.1016/j.biopsych.2021.07.025
Abstract: BACKGROUND The fetal origins of mental health is a well-established framework that currently lacks a robust index of the biological embedding of prenatal adversity. The Pediatric-Buccal-Epigenetic (PedBE) clock is a novel epigenetic tool that associates… read more here.
Keywords: fetal origins; anxiety; age; origins epigenetic ... See more keywords
DNA methylation age acceleration is associated with age of onset in Chinese spinocerebellar ataxia type 3 patients
Sign Up to like & getrecommendations! Published in 2022 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2022.02.002
Abstract: Spinocerebellar ataxia type 3 (SCA3), also known as Machado Joseph disease (MJD), is a common dominantly inherited ataxia, and has heterogeneous clinical features and variable age of onset, ranging from 10 to 78 years. Repeats… read more here.
Keywords: age; dnam age; age onset; acceleration associated ... See more keywords
Biological aging in schizophrenia and psychosis severity: DNA methylation analysis
Sign Up to like & getrecommendations! Published in 2021 at "Psychiatry Research"
DOI: 10.1016/j.psychres.2020.113646
Abstract: The physiological changes associated with normal aging are known to occur earlier in individuals with schizophrenia (SCZ). One of the phenomena linked with normal aging is the change in patterns of epigenetic modifications. We recruited… read more here.
Keywords: dna methylation; age; age acceleration; psychosis severity ... See more keywords
Early life adversity and age acceleration at mid-life and older ages indexed using the next-generation GrimAge and Pace of Aging epigenetic clocks
Sign Up to like & getrecommendations! Published in 2022 at "Psychoneuroendocrinology"
DOI: 10.1016/j.psyneuen.2021.105643
Abstract: OBJECTIVE This retrospective cross-sectional study was designed to explore whether the experience of childhood adversity was associated with epigenetic age acceleration in mid-life and older ages using the next generation GrimAge and Pace of Aging… read more here.
Keywords: age; adversity; age acceleration; life ... See more keywords
Epigenetic-based age acceleration in a representative sample of older Americans: Associations with aging-related morbidity and mortality
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2215840120
Abstract: Significance In a nationally representative US adult population, measures of epigenetic age acceleration are associated with concurrent cognitive dysfunction, functional limitations and chronic conditions measured 2 y after DNA methylation measurement, and 4-y mortality. PC-based… read more here.
Keywords: based age; morbidity mortality; age acceleration; age ... See more keywords
The effects of epigenetic age and its acceleration on surface area, cortical thickness, and volume in young adults.
Sign Up to like & getrecommendations! Published in 2022 at "Cerebral cortex"
DOI: 10.1093/cercor/bhac043
Abstract: DNA methylation age has been used in recent studies as an epigenetic marker of accelerated cellular aging, whose contribution to the brain structural changes was lately acknowledged. We aimed to characterize the association of epigenetic… read more here.
Keywords: cortical thickness; epigenetic age; volume; age ... See more keywords
Association Between Posttraumatic Stress Disorder and Epigenetic Age Acceleration in a Sample of Twins
Sign Up to like & getrecommendations! Published in 2021 at "Psychosomatic Medicine"
DOI: 10.1097/psy.0000000000001028
Abstract: Posttraumatic stress disorder (PTSD) may physiologically induce accelerated aging, which can be objectively measured by DNA methylation age acceleration. We investigated the association of a clinical diagnosis of PTSD and symptom severity of PTSD with… read more here.
Keywords: age acceleration; age; dnam age; association ... See more keywords