Adipose Tissue Plasticity in Aging.
Sign Up to like & getrecommendations! Published in 2022 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c220005
Abstract: As a dynamic endocrine organ, white adipose tissue (WAT) stores lipids and plays a critical role in maintaining whole-body energy homeostasis and insulin sensitivity. A large group of the population over 65 years old suffer… read more here.
Keywords: age associated; tissue plasticity; adipose tissue; plasticity aging ... See more keywords
Age‐associated B cells expanded in autoimmune mice are memory cells sharing H‐CDR3‐selected repertoires
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747127
Abstract: Age‐associated B cells (ABCs) represent a distinct cell population expressing low levels of CD21 (CD21−/low). The Ig repertoire expressed by ABCs in aged mice is diverse and exhibits signs of somatic hypermutation (SHM). A CD21−/low… read more here.
Keywords: autoimmune mice; expanded autoimmune; associated cells; age associated ... See more keywords
Irisin ameliorates age‐associated sarcopenia and metabolic dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13141
Abstract: Age‐associated sarcopenia is characterized of progressed loss of skeletal muscle power, mass, and function, which affects human physical activity and life quality. Besides, accompanied with sarcopenia, aged population also faces a series of metabolic dysfunctions.… read more here.
Keywords: associated sarcopenia; metabolic dysfunction; age associated; sarcopenia metabolic ... See more keywords
Short Telomeres Induce p53 and Autophagy and Modulate Age‐Associated Changes in Cardiac Progenitor Cell Fate
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS"
DOI: 10.1002/stem.2793
Abstract: Aging severely limits myocardial repair and regeneration. Delineating the impact of age‐associated factors such as short telomeres is critical to enhance the regenerative potential of cardiac progenitor cells (CPCs). We hypothesized that short telomeres activate… read more here.
Keywords: cell fate; age associated; short telomeres;
An fMRI study of age-associated changes in basic visual discrimination
Sign Up to like & getrecommendations! Published in 2020 at "Brain Imaging and Behavior"
DOI: 10.1007/s11682-020-00301-x
Abstract: Clinical neuropsychology lacks tests of basic visuoperceptual and spatial skills that have well-controlled administration and sophisticated measurement methods. Items from the Visual Assessment Battery (VAB), a simultaneous match-to-sample task, assessed visual discrimination in 40 healthy… read more here.
Keywords: task; age; visual discrimination; fmri study ... See more keywords
Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases
Sign Up to like & getrecommendations! Published in 2018 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2017.11.003
Abstract: Werner syndrome (WS) is a heritable autosomal recessive human disorder characterized by the premature onset of several age-associated pathologies including cancer. The protein defective in WS patients, WRN, is encoded by a member of the… read more here.
Keywords: age; werner syndrome; age associated; syndrome wrn ... See more keywords
Homocysteine and age-associated disorders
Sign Up to like & getrecommendations! Published in 2019 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2018.10.010
Abstract: There are numerous theories of aging, a process which still seems inevitable. Aging leads to cancer and multi-systemic disorders as well as chronic diseases. Decline in age- associated cellular functions leads to neurodegeneration and cognitive… read more here.
Keywords: age; age associated; homocysteine age; associated disorders ... See more keywords
Monoamine oxidases in age-associated diseases: New perspectives for old enzymes
Sign Up to like & getrecommendations! Published in 2021 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2021.101256
Abstract: Population aging is one of the most significant social changes of the twenty-first century. This increase in longevity is associated with a higher prevalence of chronic diseases, further rising healthcare costs. At the molecular level,… read more here.
Keywords: new perspectives; monoamine oxidases; age; associated diseases ... See more keywords
Age-associated changes in microRNAs affect the differentiation potential of human mesenchymal stem cells: Novel role of miR-29b-1-5p expression.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.116154
Abstract: Age-associated osteoporosis is widely accepted as involving the disruption of osteogenic stem cell populations and their functioning. Maintenance of the local bone marrow (BM) microenvironment is critical for regulating proliferation and differentiation of the multipotent… read more here.
Keywords: age; bone; expression; age associated ... See more keywords
Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.01.018
Abstract: The increase in life expectancy has boosted the incidence of age-related pathologies beyond social and economic sustainability. Consequently, there is an urgent need for interventions that revert or at least prevent the pathogenic age-associated deterioration.… read more here.
Keywords: age; restriction mimetics; caloric restriction; mimetics age ... See more keywords
Computational Drug Screening Identifies Compounds Targeting Renal Age-associated Molecular Profiles
Sign Up to like & getrecommendations! Published in 2019 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2019.06.019
Abstract: Aging is a major driver for chronic kidney disease (CKD) and the counterbalancing of aging processes holds promise to positively impact disease development and progression. In this study we generated a signature of renal age-associated… read more here.
Keywords: renal age; age associated; ckd; ckd progression ... See more keywords