Ameliorative effects of oyster (Crassostrea hongkongensis) protein hydrolysate on age-induced cognitive impairment via restoring glia cell dysfunction and neuronal injured in zebrafish
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2021.104607
Abstract: Abstract Cognitive impairment caused by aging is a global public health problem. The 5–8 kDa ultrafiltration fraction of oyster (Crassostrea hongkongensis) protein hydrolysate (OPU) could ameliorate learning and memory in aged zebrafish, however the mechanism is… read more here.
Keywords: age induced; opu; age; cognitive impairment ... See more keywords
Exploration of potential lipid biomarkers for age‐induced hair graying by lipidomic analyses of hair shaft roots with follicular tissue attached
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cosmetic Dermatology"
DOI: 10.1111/jocd.15150
Abstract: Age‐induced hair graying (AIHG)is one of the visual hallmarks of aging, but its biological mechanism remains unclear. Changes in the hair‐follicle lipid profiles associated with AIHG have not been defined. read more here.
Keywords: exploration potential; age induced; hair; hair graying ... See more keywords
Role of moesin, Src, and ROS in advanced glycation end product‐induced vascular endothelial dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Microcirculation"
DOI: 10.1111/micc.12358
Abstract: The disruption of endothelial integrity and the occurrence of angiogenesis in response to AGEs contribute greatly to micro‐ and macrovascular complications associated with DM. Among human dermal, brain, and retinal vascular ECs, activation of ERM,… read more here.
Keywords: moesin; dysfunction; role moesin; age induced ... See more keywords
AGEs/RAGE Promote Osteogenic Differentiation in Rat Bone Marrow-Derived Endothelial Progenitor Cells via MAPK Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Research"
DOI: 10.1155/2022/4067812
Abstract: Systemic vascular impairment is the most common complication of diabetes. Advanced glycation end products (AGEs) can exacerbate diabetes-related vascular damage by affecting the intima and media through a variety of mechanisms. In the study, we… read more here.
Keywords: differentiation; ages rage; age induced; rage ... See more keywords
Abstract 16607: Age-induced Endoplasmic Reticulum Stress in the Heart: Role of Increased Very Long-chain Ceramides
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.16607
Abstract: Introduction: Mitochondrial function is impaired in aged hearts. Increased endoplasm reticulum (ER) stress contributes to the mitochondrial dysfunction observed during aging. Ceramides (CRMD) are s... read more here.
Keywords: age induced; reticulum stress; induced endoplasmic; reticulum ... See more keywords
AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression
Sign Up to like & getrecommendations! Published in 2018 at "Translational Neurodegeneration"
DOI: 10.1186/s40035-018-0106-z
Abstract: BackgroundLeucine-rich repeat kinase 2 (LRRK2) mutations represent the most common genetic cause of sporadic and familial Parkinson’s disease (PD). Especially, LRRK2 G2019S missense mutation has been identified as the most prevalent genetic cause in the… read more here.
Keywords: age; age induced; rage; cell death ... See more keywords
Fluvastatin inhibits AGE-induced cell proliferation and migration via an ERK5-dependent Nrf2 pathway in vascular smooth muscle cells
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0178278
Abstract: Advanced glycation endproduct (AGE)-induced vascular smooth muscle cell (VSMC) proliferation and reactive oxygen species (ROS) production are emerging as important mechanisms of diabetic vasculopathy, but little is known about the molecular mechanism responsible for the… read more here.
Keywords: age induced; migration; induced cell; proliferation ... See more keywords
Quercetin modulates age-induced changes in the transcript levels of some apoptosis related genes in the skeletal muscles of male rats
Sign Up to like & getrecommendations! Published in 2020 at "Brazilian Journal of Pharmaceutical Sciences"
DOI: 10.1590/s2175-979020200003180861
Abstract: Adverse changes occur gradually in the skeletal muscles with age via continuous exposure to oxidative stress. Quercetin, a member of the flavonoids family, possesses anti-oxidative and radical-scavenging activities. Therefore, this study investigated the role of… read more here.
Keywords: age; skeletal muscles; apoptosis related; age induced ... See more keywords
Src Plays an Important Role in AGE-Induced Endothelial Cell Proliferation, Migration, and Tubulogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.00765
Abstract: Advanced glycation end products (AGEs), produced by the non-enzymatic glycation of proteins and lipids under hyperglycemia or oxidative stress conditions, has been implicated to be pivotal in the development of diabetic vascular complications, including diabetic… read more here.
Keywords: angiogenesis; role age; age; age induced ... See more keywords
The Transcriptomic Landscape of Age-Induced Changes in Human Visceral Fat and the Predicted Omentum-Liver Connectome in Males
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11051446
Abstract: Aging causes alterations in body composition. Specifically, visceral fat mass increases with age and is associated with age-related diseases. The pathogenic potential of visceral fat accumulation has been associated with its anatomical location and metabolic… read more here.
Keywords: age related; age induced; age; visceral fat ... See more keywords
Age-Induced Differential Changes in the Central and Colonic Human Circadian Oscillators
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21020674
Abstract: Aging modifies not only multiple cellular and homeostatic systems, but also biological rhythms. The circadian system is driven by a central hypothalamic oscillator which entrains peripheral oscillators, in both cases underlain by circadian genes. Our… read more here.
Keywords: central colonic; differential changes; age; changes central ... See more keywords