Xiao-Xu-Ming decoction prevented hemorrhagic transformation induced by acute hyperglycemia through inhibiting AGE-RAGE-mediated neuroinflammation.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105650
Abstract: Stroke is one of the leading causes of death worldwide. Hemorrhagic transformation (HT) is a common serious complication of ischemic stroke (IS) and is related to poor prognosis. Hyperglycemia after stroke is associated with the… read more here.
Keywords: rage mediated; mediated neuroinflammation; age rage; hyperglycemia ... See more keywords
Hypoxia driven glycation: Mechanisms and therapeutic opportunities.
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2017.05.008
Abstract: Tumor masses are deprived of oxygen and characterized by enhanced glucose uptake followed by glycolysis. Elevated glucose levels induce non-enzymatic glycosylation or glycation of proteins which leads to accumulation of advanced glycation end products (AGE).… read more here.
Keywords: hypoxia driven; age; driven glycation; cancer ... See more keywords
Protective effect of mangiferin on myocardial ischemia-reperfusion injury in streptozotocin-induced diabetic rats: role of AGE-RAGE/MAPK pathways
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42027
Abstract: Hyperglycemia induced advanced glycation end products-receptor for advanced glycation end products (AGE-RAGE) activation is thought to involve in the development of cardiovascular disease in diabetics. Activation of AGE-RAGE axis results in the oxidative stress and… read more here.
Keywords: diabetic rats; injury; age rage; mangiferin ... See more keywords
Blocking AGE-RAGE Signaling Improved Functional Disorders of Macrophages in Diabetic Wound
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Diabetes Research"
DOI: 10.1155/2017/1428537
Abstract: Advanced glycosylation end products (AGEs) accumulate in diabetic wounds. Interactions between AGEs and their receptor (RAGE) leads to dermatologic problems in diabetes. Macrophage, which plays important roles in wound healing, highly expresses RAGE. Therefore, we… read more here.
Keywords: blocking age; rage; signaling improved; age rage ... See more keywords
RAGE is a Potential Cause of Onset and Progression of Nonalcoholic Fatty Liver Disease
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Endocrinology"
DOI: 10.1155/2019/2151302
Abstract: Objective Fatty liver is a rising global health concern, significantly increasing the burden of health care cost. Nonalcoholic fatty liver disease (NAFLD) has a correlation with metabolic syndrome and its complications. Method We reviewed the… read more here.
Keywords: liver disease; age rage; fatty liver;
Lycopene Improves Bone Quality and Regulates AGE/RAGE/NF-кB Signaling Pathway in High-Fat Diet-Induced Obese Mice
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/3697067
Abstract: Objective This study was aimed at examining the effects of lycopene on bone metabolism in high-fat diet (HFD)- induced obese mice and to identify the potential underlying mechanisms. Methods Mice were fed a HFD for… read more here.
Keywords: signaling pathway; age rage; obese mice; induced obese ... See more keywords
Therapeutic Potential of DNA-aptamers Raised Against AGE-RAGE Axis in Diabetes-related Complications.
Sign Up to like & getrecommendations! Published in 2018 at "Current pharmaceutical design"
DOI: 10.2174/1381612824666180829110124
Abstract: Accumulating evidence has indicated that formation and accumulation of advanced glycation end products (AGEs) progress under diabetic conditions, thereby contributing to the development and progression of various diabetes- and aging-related disorders, such as diabetic nephropathy,… read more here.
Keywords: age; age rage; rage axis; dna ... See more keywords
Effects of Acute Experimental Hyperglycemia on Oxidative Markers and AGE-RAGE Dynamics in Obese Humans
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/db18-273-lb
Abstract: Chronic hyperglycemia promotes oxidative stress and advanced glycation end product (AGE) formation, leading to recognition by the AGE receptor (RAGE). AGE-RAGE binding and inflammation perpetuates diabetic complications, however the study of these phenomenon present inherent… read more here.
Keywords: age; oxidative markers; effects acute; rage ... See more keywords
AGE-RAGE axis culminates into multiple pathogenic processes: a central road to neurodegeneration
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1155175
Abstract: Advanced glycation end-products (AGEs; e.g., glyoxal, methylglyoxal or carboxymethyl-lysine) are heterogenous group of toxic compounds synthesized in the body through both exogenous and endogenous pathways. AGEs are known to covalently modify proteins bringing about loss… read more here.
Keywords: axis culminates; age rage; rage; rage axis ... See more keywords
Niaoduqing alleviates podocyte injury in high glucose model via regulating multiple targets and AGE/RAGE pathway: Network pharmacology and experimental validation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1047184
Abstract: Purpose: The aim of present study was to explore the pharmacological mechanisms of Niaoduqing granules on the treatment of podocyte injury in diabetic nephropathy (DN) via network pharmacology and experimental validation. Methods: Active ingredients and… read more here.
Keywords: network; pharmacology; age rage; podocyte injury ... See more keywords
The Role of AGE-RAGE Signalling as a Modulator of Gut Permeability in Diabetes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031766
Abstract: There is increasing evidence for the role of intestinal permeability as a contributing factor in the pathogenesis of diabetes; however, the molecular mechanisms are poorly understood. Advanced glycation endproducts, of both exogenous and endogenous origin,… read more here.
Keywords: role; rage signalling; age rage; role age ... See more keywords