Indole-linked 1,2,3-triazole derivatives efficiently modulate COX-2 protein levels in human THP-1 monocytes by suppressing AGE-ROS-NF-kβ nexus.
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DOI: 10.1016/j.lfs.2021.120282
Abstract: AIMS AGEs augment inflammatory responses by activating inflammatory cascade in monocytes, and hence lead to vascular dysfunction. The current study aims to study a plausible role and mechanism of new library of indole-tethered 1,2,3-triazoles 2-13… read more here.
Keywords: cox protein; protein levels; thp monocytes; suppressing age ... See more keywords