Angiotensin receptor (AT2R) agonist C21 prevents cognitive decline after permanent stroke in aged animals—A randomized double- blind pre-clinical study
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.10.010
Abstract: HighlightsC21 reduced weight loss and enhanced recovery in aged rats post‐stroke.C21 preserved non‐spatial and short‐term working memory in aged rats post‐stroke.C21 preserved reference memory and facilitated associative learning post‐stroke.C21 improved cognitive flexibility in aged rats… read more here.
Keywords: post stroke; stroke c21; aged animals; c21 ... See more keywords
Enhanced LTP in aged rats: Detrimental or compensatory?
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2016.11.017
Abstract: ABSTRACT Age‐dependent memory deterioration has been well documented and yet an increase in rat hippocampal LTP upon aging has been reported. This poses the question of whether the enhanced LTP is a cause or an… read more here.
Keywords: aged rats; ltp; aged animals; compensatory ... See more keywords
Differential effects in young and aged rats' navigational accuracy following instantaneous rotation of environmental cues.
Sign Up to like & getrecommendations! Published in 2022 at "Behavioral neuroscience"
DOI: 10.1037/bne0000536
Abstract: Successful navigation depends critically upon two broad categories of spatial navigation strategies that include allocentric and egocentric reference frames, relying on external or internal spatial information, respectively. As with older adults, aged rats show robust… read more here.
Keywords: young aged; aged rats; rotation; aged animals ... See more keywords
Present Status and Future Challenges of New Therapeutic Targets in Preclinical Models of Stroke in Aged Animals with/without Comorbidities
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19020356
Abstract: The aging process, comorbidities, and age-associated diseases are closely dependent on each other. Cerebral ischemia impacts a wide range of systems in an age-dependent manner. However, the aging process has many facets which are influenced… read more here.
Keywords: aged animals; without comorbidities; age; present status ... See more keywords
Mutant Ataxin-2 Expression in Aged Animals Aggravates Neuropathological Features Associated with Spinocerebellar Ataxia Type 2
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911896
Abstract: Spinocerebellar ataxia type 2 (SCA2) is a rare autosomal, dominantly inherited disease, in which the affected individuals have a disease onset around their third life decade. The molecular mechanisms underlying SCA2 are not yet completely… read more here.
Keywords: mutant ataxin; neuropathological features; ataxia type; spinocerebellar ataxia ... See more keywords
The neuron-specific IIS/FOXO transcriptome in aged animals reveals regulatory mechanisms of cognitive aging
Sign Up to like & getrecommendations! Published in 2024 at "eLife"
DOI: 10.7554/elife.95621
Abstract: Cognitive decline is a significant health concern in our aging society. Here, we used the model organism C. elegans to investigate the impact of the IIS/FOXO pathway on age-related cognitive decline. The daf-2 Insulin/IGF-1 receptor… read more here.
Keywords: age; cognitive aging; neuron specific; iis foxo ... See more keywords