Hyperexcitable arousal circuits drive sleep instability during aging
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DOI: 10.1126/science.abh3021
Abstract: Sleep quality declines with age; however, the underlying mechanisms remain elusive. We found that hyperexcitable hypocretin/orexin (Hcrt/OX) neurons drive sleep fragmentation during aging. In aged mice, Hcrt neurons exhibited more frequent neuronal activity epochs driving… read more here.
Keywords: kcnq2; sleep fragmentation; hcrt; hcrt neurons ... See more keywords