Induction and Detection of Autophagy in Aged Hematopoietic Stem Cells by Exposing Them to Microvesicles Secreted by HSC-Supportive Mesenchymal Stromal Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/7651_2018_166
Abstract: Autophagy is an important cellular process for maintenance of quality and functionality of cells. This happens through repair and renewal of cellular components like proteins and mitochondria. Reduction in autophagy process in aged hematopoietic stem… read more here.
Keywords: mesenchymal stromal; stromal cells; aged hematopoietic; hematopoietic stem ... See more keywords
Attrition of X Chromosome Inactivation in Aged Hematopoietic Stem Cells
Sign Up to like & getrecommendations! Published in 2021 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2021.03.007
Abstract: Summary During X chromosome inactivation (XCI), the inactive X chromosome (Xi) is recruited to the nuclear lamina at the nuclear periphery. Beside X chromosome reactivation resulting in a highly penetrant aging-like hematopoietic malignancy, little is… read more here.
Keywords: aged hematopoietic; hematopoietic stem; stem; chromosome inactivation ... See more keywords