Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.07.043
Abstract: Summary Nicotinamide adenine dinucleotide (NAD+) is modulated by conditions of metabolic stress and has been reported to decline with aging in preclinical models, but human data are sparse. Nicotinamide riboside (NR) supplementation ameliorates metabolic dysfunction… read more here.
Keywords: skeletal muscle; aged human; muscle; nicotinamide riboside ... See more keywords
Calbindin-D28K, parvalbumin, and calretinin in young and aged human locus coeruleus
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.06.006
Abstract: Certain neuronal populations, including basal forebrain cholinergic neurons (BFCN) and noradrenergic neurons of the locus coeruleus (LC), are selectively vulnerable to pathology and loss early in the course of aging and Alzheimer's disease (AD). Human… read more here.
Keywords: aged human; calbindin d28k; parvalbumin calretinin; locus coeruleus ... See more keywords
Human organ rejuvenation by VEGF-A: Lessons from the skin
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DOI: 10.1126/sciadv.abm6756
Abstract: Transplanting aged human skin onto young SCID/beige mice morphologically rejuvenates the xenotransplants. This is accompanied by angiogenesis, epidermal repigmentation, and substantial improvements in key aging-associated biomarkers, including ß-galactosidase, p16ink4a, SIRT1, PGC1α, collagen 17A, and MMP1.… read more here.
Keywords: skin; vegf; human skin; rejuvenation ... See more keywords