Exogenous recombinant Hsp70 attenuates sevoflurane anesthesia‐induced cognitive dysfunction in aged mice
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2861
Abstract: Postoperative cognitive dysfunction (POCD) is a severe postoperative neurological sequela in elderly patients, and there is currently no standard treatment for POCD. In this study, whether recombinant human heat shock protein 70 (rHsp70) could alleviate… read more here.
Keywords: cognitive dysfunction; induced cognitive; aged mice; exogenous recombinant ... See more keywords
Tanshinone IIA enhances the ovarian reserve and attenuates ovarian oxidative stress in aged mice
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary Medicine and Science"
DOI: 10.1002/vms3.811
Abstract: Abstract Background Tanshinone IIA (TSA), a major lipophilic component extracted from the roots of Salvia miltiorrhiza Bunge, has been widely used in China for its various biological activities. However, its effect on ovarian reserve in… read more here.
Keywords: ovarian reserve; aged mice; day; tanshinone iia ... See more keywords
Dexmedetomidine Ameliorates Postoperative Cognitive Dysfunction in Aged Mice.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03386-y
Abstract: Neuroinflammation and oxidative stress coexist and interact in the progression of postoperative cognitive dysfunction (POCD) and other neurodegenerative disease. Mounting studies reveal that Dexmedetomidine (Dex) possesses anti-inflammatory and antioxidant properties. Nevertheless, whether Dex exerts neuroprotective… read more here.
Keywords: surgery; dex; postoperative cognitive; cognitive dysfunction ... See more keywords
Astaxanthin supplementation modulates cognitive function and synaptic plasticity in young and aged mice
Sign Up to like & getrecommendations! Published in 2019 at "GeroScience"
DOI: 10.1007/s11357-019-00051-9
Abstract: The incidence of neurodegenerative disorders and cognitive impairment is increasing. Rising prevalence of age-related medical conditions is associated with a dramatic economic burden; therefore, developing strategies to manage these health concerns is of great public… read more here.
Keywords: plasticity young; aged mice; cognitive function; synaptic plasticity ... See more keywords
Contribution of Porphyromonas gingivalis lipopolysaccharide to experimental periodontitis in relation to aging
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DOI: 10.1007/s11357-020-00258-1
Abstract: Aging is associated with increased prevalence and severity of pathogenic outcomes of periodontal disease, including soft tissue degeneration and bone loss around the teeth. Although lipopolysaccharide (LPS) derived from the key periodontal pathogen Porphyromonas gingivalis… read more here.
Keywords: relation aging; porphyromonas gingivalis; aged mice; periodontitis relation ... See more keywords
Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice.
Sign Up to like & getrecommendations! Published in 2021 at "GeroScience"
DOI: 10.1007/s11357-021-00440-z
Abstract: Moment-to-moment adjustment of regional cerebral blood flow to neuronal activity via neurovascular coupling (NVC or "functional hyperemia") has a critical role in maintenance of healthy cognitive function. Aging-induced impairment of NVC responses importantly contributes to… read more here.
Keywords: nvc responses; abt263 navitoclax; treatment; aged mice ... See more keywords
Aging and miR-155 in mice influence survival and neuropathic pain after spinal cord injury
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2021.07.003
Abstract: Spinal cord injury (SCI) elicits chronic pain in 65% of individuals. In addition, SCI afflicts an increasing number of aged individuals, and those with SCI are predisposed to shorter lifespan. Our group previously identified that… read more here.
Keywords: mir 155; deletion; aged mice; 155 mice ... See more keywords
Recombinant growth differentiation factor 11 influences short-term memory and enhances Sox2 expression in middle-aged mice
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.12.019
Abstract: Previous evidence suggests that a significant decline in cognitive ability begins during middle-age and continues to deteriorate with increase in age. Recent work has demonstrated the potential rejuvenation impact of growth differentiation factor-11 (GDF-11) in… read more here.
Keywords: factor; short term; aged mice; middle aged ... See more keywords
Compound D159687, a phosphodiesterase 4D inhibitor, induces weight and fat mass loss in aged mice without changing lean mass, physical and cognitive function.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.10.180
Abstract: AIMS Therapies that recapitulate the health benefits of caloric restriction in older adults are needed. Phosphodiesterase 4 inhibitors demonstrate such promise. We examined their effects on body weight and composition, physical and cognitive function in… read more here.
Keywords: mass; d159687; aged mice; mice ... See more keywords
Gastrodin alleviates perioperative neurocognitive dysfunction of aged mice by suppressing neuroinflammation.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173734
Abstract: Perioperative neurocognitive disorder (PND) is a common complication of elderly patients after surgery and lacks effective prevention and treatment measures. We investigated the effect and mechanism of gastrodin (GAS), a natural plant ingredient, on postoperative… read more here.
Keywords: surgery; perioperative neurocognitive; mice subjected; gas ... See more keywords
Involvement of progranulin in modulating neuroinflammatory responses but not neurogenesis in the hippocampus of aged mice
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DOI: 10.1016/j.exger.2017.05.003
Abstract: Abstract It is well established that adult neurogenesis in the hippocampus declines with age. Our previous studies have suggested that progranulin (PGRN) has a facilitative effect on hippocampal neurogenesis. We have also shown that PGRN… read more here.
Keywords: neuroinflammatory responses; hippocampus; neurogenesis; age ... See more keywords