Teaching old mice new tricks: the utility of aged mouse models of C. difficile infection to study pathogenesis and rejuvenate immune response
Sign Up to like & getrecommendations! Published in 2021 at "Gut Microbes"
DOI: 10.1080/19490976.2021.1966255
Abstract: ABSTRACT Background Clostridioides difficile is a serious problem for the aging population. Aged mouse model of C. difficile infection (CDI) has emerged as a valuable tool to evaluate the mechanism of aging in CDI. Methods… read more here.
Keywords: aged mouse; mouse models; difficile infection; infection ... See more keywords
The N6‐methyladenosine RNA landscape in the aged mouse hippocampus
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13755
Abstract: The aged brain is associated with an inevitable decline in cognitive function and increased vulnerability to neurodegenerative disorders. Multiple molecular hallmarks have been associated with the aging nervous system through transcriptomics and proteomic studies. Recently,… read more here.
Keywords: rna; mouse hippocampus; aged mouse; hippocampus ... See more keywords
The activation of cGAS‐STING pathway causes abnormal uterine receptivity in aged mice
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DOI: 10.1111/acel.14303
Abstract: Maternal age is one of the most important factors affecting the success of maternal pregnancy. Uterine aging is the leading cause of pregnancy failure in older women. However, how uterine aging affects uterine receptivity and… read more here.
Keywords: aged mouse; sting pathway; aged mice; receptivity ... See more keywords
Metformin represses the carcinogenesis potentially induced by 50 Hz magnetic fields in aged mouse fibroblasts via inhibition of NF‐kB
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DOI: 10.1111/jcmm.70132
Abstract: Aging is a risk factor for various human disorders, including cancer. Current literature advocates that the primary principles of aging depend on the endogenous stress‐induced DNA damage caused by reactive oxygen species 50 Hz low‐frequency magnetic… read more here.
Keywords: dna damage; inhibition; aged mouse; expression ... See more keywords
Abstract 12: Deciphering the role of oncogenic integrin alpha 6B in aged mouse mammary epithelial cells
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-12
Abstract: Breast cancer (BC) is the most diagnosed cancer in women with aging being the major risk factor. According to American Cancer Society (2024), an estimation of 310, 720 invasive BC and about 56, 500 cases… read more here.
Keywords: cancer; integrin; aged mouse; mouse mammary ... See more keywords