Nampt affects mitochondrial function in aged oocytes by mediating the downstream effector FoxO3a.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30532
Abstract: Maternal aging can impair the quality and decrease the developmental competence of ovulated oocytes. In this study, compromised germinal vesicle breakdown (GVBD) was found in aged mice oocytes. Furthermore, we observed increased reactive oxygen species… read more here.
Keywords: mitochondrial function; foxo3a; affects mitochondrial; nampt affects ... See more keywords
Improvement of early developmental competence of postovulatory‐aged oocytes using metaphase II spindle injection in mice
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12335
Abstract: Assisted reproductive technology (ART) is a widely applied fertility treatment. However, the developmental competence of aged oocytes from women of a late reproductive age is seriously reduced and the aged oocytes often fail in fertilization… read more here.
Keywords: developmental competence; metaphase spindle; improvement early; aged oocytes ... See more keywords
Association Between Functional Activity of Mitochondria and Actin Cytoskeleton Instability in Oocytes from Advanced Age Mice
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DOI: 10.1007/s43032-020-00145-2
Abstract: Mitochondrial dysfunction is strongly associated with the oocyte quality and aging, wherein the aged oocytes are related to the actin cytoskeleton integrity; however, whether this integrity is associated with mitochondrial dysfunction in oocytes from aged… read more here.
Keywords: cytoskeleton; actin cytoskeleton; aged oocytes; cytoskeleton instability ... See more keywords
Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes.
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DOI: 10.1016/j.celrep.2020.107987
Abstract: Advanced maternal age is highly associated with a decline in oocyte quality, but effective approaches to improve it have still not been fully determined. Here, we report that in vivo supplementation of nicotinamide mononucleotide (NMN) efficaciously… read more here.
Keywords: supplementation; quality; nicotinamide mononucleotide; mononucleotide supplementation ... See more keywords
SIRT1 reduces epigenetic and non-epigenetic changes to maintain the quality of postovulatory aged oocytes in mice.
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DOI: 10.1016/j.yexcr.2020.112421
Abstract: Postovulatory oocyte aging has a major influence on the development potential of embryos. Many antioxidants can delay oocyte aging by regulating the expression of SIRT1. However, there is a lack of knowledge on SIRT1 function… read more here.
Keywords: sirt1; oocyte aging; postovulatory aged; epigenetic changes ... See more keywords
The Antioxidant Auraptene Improves Aged Oocyte Quality and Embryo Development in Mice
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DOI: 10.3390/antiox12010087
Abstract: Decrease in quality of postovulatory aged oocytes occurs due to oxidative stress and leads to low fertilization and development competence. It is one of the main causes that exerting detrimental effect on the success rate… read more here.
Keywords: aged oocytes; quality; development; oxidative stress ... See more keywords