Nampt affects mitochondrial function in aged oocytes by mediating the downstream effector FoxO3a.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30532
Abstract: Maternal aging can impair the quality and decrease the developmental competence of ovulated oocytes. In this study, compromised germinal vesicle breakdown (GVBD) was found in aged mice oocytes. Furthermore, we observed increased reactive oxygen species… read more here.
Keywords: mitochondrial function; foxo3a; affects mitochondrial; nampt affects ... See more keywords
Improvement of early developmental competence of postovulatory‐aged oocytes using metaphase II spindle injection in mice
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12335
Abstract: Assisted reproductive technology (ART) is a widely applied fertility treatment. However, the developmental competence of aged oocytes from women of a late reproductive age is seriously reduced and the aged oocytes often fail in fertilization… read more here.
Keywords: developmental competence; metaphase spindle; improvement early; aged oocytes ... See more keywords
Association Between Functional Activity of Mitochondria and Actin Cytoskeleton Instability in Oocytes from Advanced Age Mice
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Sciences"
DOI: 10.1007/s43032-020-00145-2
Abstract: Mitochondrial dysfunction is strongly associated with the oocyte quality and aging, wherein the aged oocytes are related to the actin cytoskeleton integrity; however, whether this integrity is associated with mitochondrial dysfunction in oocytes from aged… read more here.
Keywords: cytoskeleton; actin cytoskeleton; aged oocytes; cytoskeleton instability ... See more keywords
Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107987
Abstract: Advanced maternal age is highly associated with a decline in oocyte quality, but effective approaches to improve it have still not been fully determined. Here, we report that in vivo supplementation of nicotinamide mononucleotide (NMN) efficaciously… read more here.
Keywords: supplementation; quality; nicotinamide mononucleotide; mononucleotide supplementation ... See more keywords
SIRT1 reduces epigenetic and non-epigenetic changes to maintain the quality of postovulatory aged oocytes in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112421
Abstract: Postovulatory oocyte aging has a major influence on the development potential of embryos. Many antioxidants can delay oocyte aging by regulating the expression of SIRT1. However, there is a lack of knowledge on SIRT1 function… read more here.
Keywords: sirt1; oocyte aging; postovulatory aged; epigenetic changes ... See more keywords
Near infrared LED Irradiation Reverses the Declining Quality of Mice Post-Ovulatory Aging and Reproductive Aged Oocytes.
Sign Up to like & getrecommendations! Published in 2025 at "Biology of reproduction"
DOI: 10.1093/biolre/ioaf129
Abstract: The advanced maternal age is strongly correlated with a notable decline in oocyte quality, yet definitive and effective strategies to enhance it remain incompletely identified. In this study, we reported that near-infrared light, administered in… read more here.
Keywords: reproductive aged; quality; post ovulatory; aged oocytes ... See more keywords
The Antioxidant Auraptene Improves Aged Oocyte Quality and Embryo Development in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox12010087
Abstract: Decrease in quality of postovulatory aged oocytes occurs due to oxidative stress and leads to low fertilization and development competence. It is one of the main causes that exerting detrimental effect on the success rate… read more here.
Keywords: aged oocytes; quality; development; oxidative stress ... See more keywords
Tauroursodeoxycholic Acid Enhances the Quality of Postovulatory Aged Oocytes by Alleviating Oxidative Stress, Apoptosis, and Endoplasmic Reticulum Stress in Pigs
Sign Up to like & getrecommendations! Published in 2025 at "Veterinary Sciences"
DOI: 10.3390/vetsci12030265
Abstract: Simple Summary The objective of this study is to evaluate the effects of TUDCA on the quality of aged porcine oocytes. Our results show that the supplementation of TUDCA to the porcine in vitro maturation… read more here.
Keywords: quality; aged oocytes; stress; oxidative stress ... See more keywords