Carnosol alleviates sevoflurane‑induced cognitive dysfunction by mediating NF‑κB pathway in aged rats
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21963
Abstract: Postoperative Cognitive Dysfunction (POCD) is a neurological disorder of unconsciousness due to cognitive regression after surgical anesthesia. However, the specific mechanism has not yet been clarified. Sevoflurane (SEV) is one of the most commonly used… read more here.
Keywords: cognitive dysfunction; effects carnosol; aged rats; sev mediated ... See more keywords
From adolescent to elder rats: Motivation for palatable food and cannabinoids receptors
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22472
Abstract: To analyze motivation, food self‐administration and decision‐making were evaluated in adolescent, adult, and aged rats. Subjects were trained to press a lever (fixed ratio, FR1 and FR5) in an operant chamber, to obtain chocolate flavor… read more here.
Keywords: aged rats; adolescent rats; adult aged; motivation palatable ... See more keywords
Buttermilk and Krill Oil Phospholipids Improve Hippocampal Insulin Resistance and Synaptic Signaling in Aged Rats
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-0934-y
Abstract: Impaired glucose metabolism and mitochondrial decay greatly increase with age, when cognitive decline becomes rampant. No pharmacological or dietary intervention has proven effective, but proper diet and lifestyle do postpone the onset of neurodegeneration and… read more here.
Keywords: aged rats; insulin; synaptic signaling; insulin resistance ... See more keywords
Effect of Initial Aging and High-Fat/High-Fructose Diet on Mitochondrial Bioenergetics and Oxidative Status in Rat Brain
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-1617-z
Abstract: Middle age is an early stage of the aging process, during which the consumption of diets rich in saturated fats and/or simple sugars might influence brain function, but only few data are available on this… read more here.
Keywords: aged rats; initial aging; middle aged; brain ... See more keywords
Lipopolysaccharide Induces Gliotoxicity in Hippocampal Astrocytes from Aged Rats: Insights About the Glioprotective Roles of Resveratrol.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02664-8
Abstract: Astrocytes may undergo a functional remodeling with aging, acquiring a pro-inflammatory state. In line with this, resveratrol represents an interesting strategy for a healthier brain aging since it can improve glial functions. In the present… read more here.
Keywords: astrocyte cultures; resveratrol; gliotoxicity hippocampal; resveratrol lipopolysaccharide ... See more keywords
Aged rats have an altered immune response and worse outcomes after traumatic brain injury
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2019.04.038
Abstract: Initial studies suggest that increased age is associated with worse outcomes after traumatic brain injury (TBI), though the pathophysiological mechanisms responsible for this remain unclear. Immunosenescence (i.e., dysregulation of the immune system due to aging)… read more here.
Keywords: aged rats; worse outcomes; response; outcomes traumatic ... See more keywords
Anti-RAGE antibody attenuates isoflurane-induced cognitive dysfunction in aged rats
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.01.012
Abstract: HighlightsIsoflurane exposure induced impairment of hippocampus‐dependent spatial learning and memory in aged rats.RAGE antibody administration improve the BBB disruption, reduce the neuroinflamation and A&bgr; deposition.RAGE antibody administration attenuated the cognitive impairment induced by isoflurane exposure.… read more here.
Keywords: aged rats; exposure; rage; isoflurane ... See more keywords
Behaviour consistency is a sensitive tool for distinguishing the effects of aging on physical activity
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2020.112619
Abstract: We attempted to establish a novel parameter of behaviour consistency to help determine the effect of age on physical activity. Using the speed of movement to quantify behaviour might not be sufficient to determine this… read more here.
Keywords: aged rats; behaviour; consistency; middle aged ... See more keywords
High-fat/high-sucrose diet results in higher bone mass in aged rats
Sign Up to like & getrecommendations! Published in 2018 at "Bone Reports"
DOI: 10.1016/j.bonr.2018.01.001
Abstract: Intake of high-fat/high-sucrose (HFS) diet or high fat diet influences bone metabolism in young rodents, but its effects on bone properties of aged rodents still remain unclear. This study aimed to examine the effects of… read more here.
Keywords: aged rats; group; hfs diet; bone ... See more keywords
Aging related functional and structural changes in the heart and aorta: MitoTEMPO improves aged-cardiovascular performance
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2018.06.012
Abstract: &NA; Aging in humans represents declining in cardio‐protective systems, however its mechanisms are not known yet. We aimed to analyse how aging affects key mechanisms responsible for contractile dysfunction via comparing the improperly synchrony between… read more here.
Keywords: aged rats; antioxidant capacity; heart; aging related ... See more keywords
Cortical and hippocampal expression of inflammatory and intracellular signaling proteins in aged rats submitted to aerobic and resistance physical training
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2018.06.025
Abstract: &NA; Aging is often accompanied by an increase in pro‐inflammatory markers. This inflammatory process is directly related to cellular dysfunctions that induce events such as the exacerbated activation of cell death signaling pathways. In the… read more here.
Keywords: aged rats; training; inflammatory; resistance ... See more keywords