Normal ageing of the brain: Histological and biological aspects.
Sign Up to like & getrecommendations! Published in 2020 at "Revue neurologique"
DOI: 10.1016/j.neurol.2020.03.017
Abstract: All the hallmarks of ageing are observed in the brain, and its cells, especially neurons, are characterized by their remarkably long lifetime. Like any organ or system, the brain is exposed to ageing processes which… read more here.
Keywords: normal ageing; ageing brain; brain histological; biological aspects ... See more keywords
Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity
Sign Up to like & getrecommendations! Published in 2021 at "Aging Cell"
DOI: 10.1111/acel.13334
Abstract: Little is known about age‐dependent changes in structure and function of astrocytes and of the impact of these on the cognitive decline in the senescent brain. The prevalent view on the age‐dependent increase in reactive… read more here.
Keywords: age dependent; ageing brain; dystrophy ageing; impaired synaptic ... See more keywords
Association of cortical microinfarcts and cerebral small vessel pathology in the ageing brain
Sign Up to like & getrecommendations! Published in 2017 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12366
Abstract: Cortical microinfarcts (CMI) are frequently observed in the ageing brain independent of cognitive decline, but their aetiology is not fully elucidated. To examine the potential role of different vessel pathologies, including cerebral amyloid angiopathy (CAA),… read more here.
Keywords: vessel; pathology; ageing brain; cortical microinfarcts ... See more keywords
Cannabinoid 1 receptor signaling on GABAergic neurons influences astrocytes in the ageing brain
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0202566
Abstract: Astrocytes, key regulators of brain homeostasis, interact with neighboring glial cells, neurons and the vasculature through complex processes involving different signaling pathways. It is not entirely clear how these interactions change in the ageing brain… read more here.
Keywords: gaba cnr1; cnr1 mice; ageing brain; brain ... See more keywords
Interplay of Ferritin Accumulation and Ferroportin Loss in Ageing Brain: Implication for Protein Aggregation in Down Syndrome Dementia, Alzheimer’s, and Parkinson’s Diseases
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031060
Abstract: Iron accumulates in the ageing brain and in brains with neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and Down syndrome (DS) dementia. However, the mechanisms of iron deposition and… read more here.
Keywords: ferroportin; iron; brain; ageing brain ... See more keywords