A Visible‐ and NIR‐Light Responsive Photothermal Therapy Agent by Chirality‐Dependent MoO3−x Nanoparticles
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201906311
Abstract: Chirality‐based semiconducting nanocrystals, as an emerging area, are envisioned to have great potential in chiral sensing, biomedicine, and chiroptical devices. Herein, chiral substoichiometric molybdenum oxide (l/d‐Cys‐MoO3−x) nanoparticles are synthesized via step‐by‐step reduction treatment with chiral… read more here.
Keywords: agent; moo3 nanoparticles; photothermal therapy; chirality ... See more keywords
A Novel Coacervate Embolic Agent for Tumor Chemoembolization
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202304488
Abstract: Transcatheter arterial chemoembolization (TACE) has proven effective in blocking tumor‐supplied arteries and delivering localized chemotherapeutic treatment to combat tumors. However, traditional embolic TACE agents exhibit certain limitations, including insufficient chemotherapeutic drug‐loading and sustained‐release capabilities, non‐biodegradability,… read more here.
Keywords: tumor chemoembolization; coacervate; embolic agent; agent ... See more keywords
A Concerted Redox‐ and Light‐Activated Agent for Controlled Multimodal Therapy against Hypoxic Cancer Cells
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202210363
Abstract: Hypoxia represents a remarkably exploitable target for cancer therapy, is encountered only in solid human tumors, and is highly associated with cancer resistance and recurrence. Here, a hypoxia‐activated mitochondria‐accumulated Ru(II) polypyridyl prodrug functionalized with conjugated… read more here.
Keywords: cancer; controlled multimodal; agent; hypoxic ... See more keywords
Time for the Next Step in Clinical Trial Evolution?
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Neurology"
DOI: 10.1002/ana.26655
Abstract: In this issue of Annals of Neurology, Pittock and colleagues report the primary outcome of a phase 3 clinical trial of ravulizumab for aquaporin-4-positive neuromyelitis optica spectrum disorder (NMOSD). Ravulizumab is a second-in-class terminal complement… read more here.
Keywords: medication; neurology; agent; trial ... See more keywords
Soy protein isolate nanocomposite film enriched with eugenol, an antimicrobial agent: Interactions and properties
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Polymer Science"
DOI: 10.1002/app.45941
Abstract: Nanocomposites films were designed from soy protein isolates (SPI), clays (Na+-MMT), and eugenol an antimicrobial agent. Interactions between Na+-MMT and eugenol were evidenced by a shift of the d-spacing by X-ray diffraction analysis. The addition… read more here.
Keywords: agent; antimicrobial agent; eugenol antimicrobial; soy protein ... See more keywords
Fully distributed coordination learning control of second‐order nonlinear multi‐agent systems with input saturation
Sign Up to like & getrecommendations! Published in 2020 at "Asian Journal of Control"
DOI: 10.1002/asjc.2330
Abstract: This paper develops the coordination learning control of second‐order non‐linear multi‐agent systems with input saturation. Fully distributed learning consensus protocols with fully saturated parameter adaptive updating laws are designed. Although there exists input saturation in… read more here.
Keywords: control second; agent; learning control; coordination learning ... See more keywords
Observer‐based distributed dynamic event‐triggered control of multi‐agent systems with adjustable interevent time
Sign Up to like & getrecommendations! Published in 2024 at "Asian Journal of Control"
DOI: 10.1002/asjc.3385
Abstract: In this paper, a novel dynamic event‐triggered control protocol for leader‐following problems of generic linear multi‐agent systems is proposed. Compared with the existing static event‐triggered strategy, the developed event‐triggered approach significantly reduces the utilization of… read more here.
Keywords: agent; control; event triggered; interevent time ... See more keywords
The Photosensitising Clinical Agent Verteporfin Is an Inhibitor of SPAK and OSR1 Kinases
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800272
Abstract: STE20/SPS1‐related proline/alanine‐rich kinase (SPAK) and oxidative‐stress‐responsive kinase 1 (OSR1) are two serine/threonine protein kinases that play key roles in regulating ion homeostasis. Various SPAK and OSR1 mouse models exhibited reduced blood pressure. Herein, the discovery of… read more here.
Keywords: agent; spak; verteporfin; osr1 kinases ... See more keywords
New methods for resolution of hydroxychloroquine by forming diastereomeric salt and adding chiral mobile phase agent on RP-HPLC.
Sign Up to like & getrecommendations! Published in 2024 at "Chirality"
DOI: 10.1002/chir.23672
Abstract: Hydroxychloroquine (HCQ), 2-([4-([7-Chloro-4-quinolyl]amino)pentyl]ethylamino)ethanol, exhibited significant biological activity, while its side effects cannot be overlooked. The RP-HPLC enantio-separation was investigated for cost-effective and convenient optical purity analysis of HCQ. The thermodynamic resolution of Rac-HCQ, driven by… read more here.
Keywords: agent; salt; hcq; mobile phase ... See more keywords
Chemosensitivity‐Gene Expression Correlations and Functional Enrichment Analysis Provide Insight into the Mechanism of Action of a Platinum‐Acridine Anticancer Agent
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200331
Abstract: NCI‐60 growth inhibition and gene expression profiles were analyzed using Pearson correlation and functional enrichment computational tools to demonstrate critical mechanistic differences between a nucleolus‐targeting platinum‐acridine anticancer agent (PA) and other DNA‐directed chemotherapies. The results… read more here.
Keywords: functional enrichment; agent; platinum acridine; gene expression ... See more keywords
Synthesis of a Bifunctional Cross‐Bridged Chelating Agent, Peptide Conjugation, and Comparison of 68Ga Labeling and Complex Stability Characteristics with Established Chelators
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200495
Abstract: [68Ga]Ga3+ can be introduced into receptor‐specific peptidic carriers via different chelators to obtain radiotracers for Positron Emission Tomography imaging and the chosen chelating agent considerably influences the in vivo pharmacokinetics of the corresponding radiopeptides. A chelator… read more here.
Keywords: cross bridged; bridged chelating; bifunctional cross; established chelators ... See more keywords