Pt(IV) Prodrug as a Potential Antitumor Agent with APE1 Inhibitory Activity.
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DOI: 10.1021/acs.jmedchem.2c01318
Abstract: The base excision repair (BER) pathway is essential for cancer cells to resist chemotherapeutic treatment, but its significance is underrated. The present study describes a novel Pt(IV) prodrug, AP1, targeting a critical BER protein, apurinic/apyrimidinic… read more here.
Keywords: antitumor agent; agent ape1; activity; potential antitumor ... See more keywords