The searching for agents for Alzheimer’s disease treatment via the system of self-consistent models
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2022.2053918
Abstract: Abstract Robust quantitative structure-activity relationships (QSARs) for hBACE-1 inhibitors (pIC50) for a large database (n = 1706) are established. New statistical criteria of the predictive potential of models are suggested and tested. These criteria are the index… read more here.
Keywords: consistent models; searching agents; agents alzheimer; system self ... See more keywords
Comparative efficacy and acceptability of antidiabetic agents for Alzheimer's disease and mild cognitive impairment: A systematic review and network meta‐analysis
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DOI: 10.1111/dom.13373
Abstract: This study (registered with PROSPERO, CRD42018085967) compares the efficacy (i.e. pro‐cognitive effects) and acceptability of antidiabetic agents for Alzheimer's disease (AD) and mild cognitive impairment (MCI). Cochrane Library (CENTRAL), PubMed/MEDLINE, EMBASE and PsycINFO were searched… read more here.
Keywords: acceptability; alzheimer disease; agents alzheimer; acceptability antidiabetic ... See more keywords
Bis-γ-carbolines as new potential multitarget agents for Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Pure and Applied Chemistry"
DOI: 10.1515/pac-2019-1206
Abstract: Abstract A new series of homobivalent Dimebon analogs, bis-γ-carbolines with alkylene, phenylenedialkylene, and triazole-containing spacers, was synthesized. Doubling the γ-carboline pharmacophore increased inhibitory potency against acetylcholinesterase (AChE) compared with Dimebon, while keeping Dimebon’s anti-butyrylcholinesterase activity;… read more here.
Keywords: agents alzheimer; alzheimer disease; multitarget agents; bis carbolines ... See more keywords