8-Ethynylxanthines as promising antiproliferative agents, angiogenesis inhibitors, and calcium channel activity modulators
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DOI: 10.1007/s10593-020-02730-4
Abstract: Synthetic procedures for the preparation of 8-ethynylxanthines by treating 8-bromocaffeine and 8-bromopentoxifylline with terminal acetylenes were elaborated. Certain ethynylxanthine derivatives exhibit high in vitro antiproliferative activity against a panel of cancer cell lines, matrix metalloproteinase… read more here.
Keywords: ethynylxanthines promising; antiproliferative agents; agents angiogenesis; channel ... See more keywords