Thienopyrimidine‐based agents bearing diphenylurea: Design, synthesis, and evaluation of antiproliferative and antiangiogenic activity
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DOI: 10.1002/ardp.202200349
Abstract: An important role has been considered for the vascular endothelial growth factor receptor 2 (VEGFR‐2) in the angiogenesis process, so that its inhibition is an important scientific way for cancer treatment. In this work, new… read more here.
Keywords: thienopyrimidine based; bearing diphenylurea; activity; sw480 huvec ... See more keywords
Quinazolin-4(3H)-one based agents bearing thiadiazole-urea: Synthesis and evaluation of anti-proliferative and antiangiogenic activity.
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DOI: 10.1016/j.bioorg.2020.104553
Abstract: A series of quinazolin-4(3H)-one based agents containing thiadiazole-urea were designed, synthesized, and biologically evaluated. The proliferation rate of PC3 cells was moderately reduced by compound 9f (IC50 = 17.7 μM)which was comparable with sorafenib (IC50 = 17.3 μM). There… read more here.
Keywords: agents bearing; based agents; one based; quinazolin one ... See more keywords