7‐Amidocoumarins as Multitarget Agents against Neurodegenerative Diseases: Substitution Pattern Modulation
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DOI: 10.1002/cmdc.202000454
Abstract: This study explores the potential of 7‐amidocoumarins as multitarget agents against Parkinson's and Alzheimer's diseases, by modulating the substitution patterns within the scaffold. Sixteen compounds were synthesized via 7‐amino‐4‐methylcoumarin acylation, and in vitro evaluation of the… read more here.
Keywords: substitution pattern; amidocoumarins multitarget; multitarget agents; substitution ... See more keywords
Natural therapeutic agents for neurodegenerative diseases from the shells of Xanthoceras sorbifolium.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104038
Abstract: Neuroinflammation is linked to neurodegenerative diseases, manifested by the microglial-released over-production of nitric oxide (NO). However, so far there is no effective strategy regarding curing or preventing neurodegenerative diseases. Triterpene saponins from Xanthoceras sorbifolium were… read more here.
Keywords: xanthoceras sorbifolium; neurodegenerative diseases; natural therapeutic; diseases shells ... See more keywords
Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases
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DOI: 10.3390/antiox11030493
Abstract: Plant-derived (phyto) carbazole alkaloids are an important class of compounds, presented in the family of Rutaceae (Genera Murraya, Clausena, Glycosmis, Micromelum and Zanthoxylum). Due to several significant biological activities, such as antitumor, antibacterial, antiviral, antidiabetic,… read more here.
Keywords: phyto carbazole; family; agents neurodegenerative; carbazole alkaloids ... See more keywords
Anthocyanins and Their Metabolites as Therapeutic Agents for Neurodegenerative Disease
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DOI: 10.3390/antiox8090333
Abstract: Neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS), are characterized by the death of neurons within specific regions of the brain or spinal cord. While the etiology of many neurodegenerative diseases… read more here.
Keywords: metabolites therapeutic; neurodegenerative diseases; anthocyanins metabolites; disease ... See more keywords