Therapeutic agents for targeting desmoplasia: current status and emerging trends.
Sign Up to like & getrecommendations! Published in 2020 at "Drug discovery today"
DOI: 10.1016/j.drudis.2020.09.008
Abstract: Desmoplasia is a major barrier to chemotherapy in several cancers, particularly pancreatic ductal adenocarcinoma and breast cancer. Tumors comprise cellular and noncellular components and chemoresistant cancer stem cells (CSCs) with established signaling pathways. In this… read more here.
Keywords: targeting desmoplasia; current status; desmoplasia; agents targeting ... See more keywords
Benzothiopyranoindole- and pyridothiopyranoindole-based antiproliferative agents targeting topoisomerases.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.01.015
Abstract: New benzothiopyranoindoles (5a-l) and pyridothiopyranoindoles (5m-t), featuring different combinations of substituents (H, Cl, OCH3) at R2-R4 positions and protonatable R1-dialkylaminoalkyl chains, were synthesized and biologically assayed on three human tumor cell lines, showing significant antiproliferative… read more here.
Keywords: benzothiopyranoindole pyridothiopyranoindole; targeting topoisomerases; pyridothiopyranoindole based; antiproliferative agents ... See more keywords
Development of selective agents targeting serotonin 5HT1A receptors with subnanomolar activities based on a coumarin core.
Sign Up to like & getrecommendations! Published in 2017 at "MedChemComm"
DOI: 10.1039/c7md00281e
Abstract: A series of 18 new 5-[3-(4-aryl-1-piperazinyl)propoxy]coumarin derivatives from the corresponding bromoalkyl derivatives have been designed and synthesized by us using a microwave-assisted protocol. Radioligand binding assays of this series of compounds as well as a… read more here.
Keywords: targeting serotonin; development selective; 5ht1a receptors; serotonin 5ht1a ... See more keywords
Organometallic anti-tumor agents: targeting from biomolecules to dynamic bioprocesses.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Society reviews"
DOI: 10.1039/d2cs00757f
Abstract: The great clinical success of cisplatin and its derivatives has convinced people that metal complexes could play a more significant role in human cancer therapy. However, targeting and drug resistance are still two dominant problems… read more here.
Keywords: organometallic anti; tumor agents; anti tumor; dynamic bioprocesses ... See more keywords
Investigational Agents Targeting SGLT1 and SGLT2 in the Treatment of Type 2 Diabetes Mellitus.
Sign Up to like & getrecommendations! Published in 2023 at "Current drug targets"
DOI: 10.2174/1389450124666230503120930
Abstract: Targeting sodium-dependent glucose transporters (SGLT1 and SGLT2) represents a new class of pharmacotherapy for type 2 diabetes mellitus, a major global health issue with an increasing social and economic burden. Following recent successes in market… read more here.
Keywords: investigational agents; type diabetes; sglt1 sglt2; diabetes mellitus ... See more keywords
Indole-based, Antiproliferative Agents Targeting Tubulin Polymerization.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026616666160530154812
Abstract: Indole is a potential lead for drug design which has been found in numerous pharmaceutically important compounds due to its medicinal properties, such as anti-tumor, anti-bacterial, anti-virus and anti-inflammatory. In the last decade, interfering with… read more here.
Keywords: targeting tubulin; polymerization; tubulin polymerization; agents targeting ... See more keywords
Progression of Antiviral Agents Targeting Viral Polymerases
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DOI: 10.3390/molecules27217370
Abstract: Viral DNA and RNA polymerases are two kinds of very important enzymes that synthesize the genetic materials of the virus itself, and they have become extremely favorable targets for the development of antiviral drugs because… read more here.
Keywords: viral polymerases; antiviral agents; targeting viral; progression antiviral ... See more keywords
A Systematic Review of Molecular Imaging Agents Targeting Bradykinin B1 and B2 Receptors
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceuticals"
DOI: 10.3390/ph13080199
Abstract: Kinins, bradykinin and kallidin are vasoactive peptides that signal through the bradykinin B1 and B2 receptors (B1R and B2R). B2R is constitutively expressed in healthy tissues and mediates responses such as vasodilation, fluid balance and… read more here.
Keywords: systematic review; imaging agents; agents targeting; bradykinin ... See more keywords