Design, synthesis and biological evaluation of Schiff’s base derivatives as multifunctional agents for the treatment of Alzheimer’s disease
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DOI: 10.1007/s00044-020-02666-6
Abstract: A series of Schiff’s base derivatives was rationally designed, synthesized, and evaluated as multi-function agents for the treatment of Alzheimer’s disease (AD). The results revealed that compound 3b was a novel multifunctional agent. It acted… read more here.
Keywords: alzheimer disease; base derivatives; agents treatment; treatment alzheimer ... See more keywords
Targeted synthesis and biological activity of polypharmacophoric agents for the treatment of neurodegenerative diseases
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DOI: 10.1007/s11172-017-1953-y
Abstract: Synthetic approaches to the design of new multitarget agents for the treatment of neurodegenerative diseases are surveyed. These approaches are based on the conjugation of the pharmacophoric indole, phenothiazine, and aminoadamantane moieties via 1-oxopropylene and… read more here.
Keywords: agents treatment; treatment neurodegenerative; neurodegenerative diseases; biological activity ... See more keywords
Novel Agents in the Treatment of Thymic Malignancies
Sign Up to like & getrecommendations! Published in 2017 at "Current Treatment Options in Oncology"
DOI: 10.1007/s11864-017-0495-8
Abstract: Opinion statementThe management of thymic tumours is a paradigm of multidisciplinary collaboration. Chemotherapy may be administered part of curative-intent sequential strategy integrating subsequent surgery or radiotherapy, or as an exclusive treatment if local treatment is… read more here.
Keywords: thymic malignancies; treatment; novel agents; treatment thymic ... See more keywords
Novel salicylamide derivatives as potent multifunctional agents for the treatment of Alzheimer's disease: Design, synthesis and biological evaluation.
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DOI: 10.1016/j.bioorg.2018.11.022
Abstract: A series of salicylamide derivatives were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer's disease. In vitro assays demonstrated that most of the derivatives were selective AChE inhibitors. They showed good… read more here.
Keywords: alzheimer disease; treatment; salicylamide derivatives; agents treatment ... See more keywords
Past, Current, and Future Developments of Therapeutic Agents for Treatment of Chronic Hepatitis B Virus Infection.
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DOI: 10.1021/acs.jmedchem.6b01442
Abstract: For decades, treatment of hepatitis B virus (HBV) infection has been relying on interferon (IFN)-based therapies and nucleoside/nucleotide analogues (NAs) that selectively target the viral polymerase reverse transcriptase (RT) domain and thereby disrupt HBV viral… read more here.
Keywords: treatment; infection; hepatitis virus; agents treatment ... See more keywords
The role of antiangiogenic agents in the treatment of gastric cancer: A systematic review and meta-analysis: Erratum
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DOI: 10.1097/md.0000000000007230
Abstract: [This corrects the article DOI: 10.1097/MD.0000000000006301.]. read more here.
Keywords: role antiangiogenic; treatment gastric; gastric cancer; antiangiogenic agents ... See more keywords
Anti-trafficking agents in the treatment of inflammatory bowel disease.
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Gastroenterology"
DOI: 10.1097/mog.0000000000000579
Abstract: PURPOSE OF REVIEW To describe the latest developments in the field of anti-trafficking agents (ATAs), a class of therapeutics with growing importance in the field of inflammatory bowel diseases (IBDs) that specifically inhibit steps of… read more here.
Keywords: trafficking agents; agents treatment; anti trafficking; inflammatory bowel ... See more keywords
Efficacy and safety of topical agents in the treatment of melasma: What's evidence? A systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cosmetic Dermatology"
DOI: 10.1111/jocd.15566
Abstract: Various topical agents have been used to treat melasma; however, a large‐scale evaluation among the currently available treatment is lacking. read more here.
Keywords: topical agents; safety topical; efficacy safety; treatment ... See more keywords
Glial-modulating agents for the treatment of pain: protocol for a systematic review
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DOI: 10.1136/bmjopen-2021-055713
Abstract: Introduction Evidence suggests a role for Central nervous system glia in pain transmission and in augmenting maladaptive opioid effects. Identification of drugs that modulate glia has guided the evaluation of glial suppression as a pain… read more here.
Keywords: systematic review; modulating agents; pain; glial modulating ... See more keywords
Design, Synthesis and Biological Evaluation of New 3,4-Dihydro-2(1H)-Quinolinone-Dithiocarbamate Derivatives as Multifunctional Agents for the Treatment of Alzheimer’s Disease
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DOI: 10.2147/dddt.s354879
Abstract: Background Alzheimer’s disease (AD) belongs to neurodegenerative disease, and the increasing number of AD patients has placed a heavy burden on society, which needs to be addressed urgently. ChEs/MAOs dual-target inhibitor has potential to treat… read more here.
Keywords: dihydro quinolinone; disease; alzheimer disease; quinolinone dithiocarbamate ... See more keywords
Development of Neuroprotective Agents for the Treatment of Alzheimer's Disease Using Conjugates of Serotonin with Sesquiterpene Lactones.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867330666221125105253
Abstract: Sesquiterpene lactones are secondary plant metabolites with a wide variety of biological activities. The process of lactone conjugation to other pharmacophores can increase the efficacy and specificity of the conjugated agent effect on molecular targets… read more here.
Keywords: alzheimer disease; disease using; sesquiterpene lactones; agents treatment ... See more keywords