RAGE-NF-κB-PPARγ Signaling is Involved in AGEs-Induced Upregulation of Amyloid-β Influx Transport in an In Vitro BBB Model
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicity Research"
DOI: 10.1007/s12640-017-9784-z
Abstract: The receptor for advanced glycation end products (RAGE) at the blood-brain barrier (BBB) is critical for regulation of amyloid-β (Aβ) homeostasis in the diabetic brain. In this study, we used an in vitro BBB model… read more here.
Keywords: ppar; ages induced; bbb; transport ... See more keywords
The GPR55 antagonist CID16020046 mitigates advanced glycation end products (AGEs)- induced chondrocyte activation.
Sign Up to like & getrecommendations! Published in 2020 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2020.109088
Abstract: Osteoarthritis (OA) is one of the most common degenerative joint diseases in aging people. The activation of chondrocytes and their dysregulation are closely related to the pathogenesis of OA. GPR55 is an unique orphan G-receptor… read more here.
Keywords: cid16020046; ages induced; antagonist cid16020046; glycation end ... See more keywords
Matrine alleviates AGEs‐ induced cardiac dysfunctions by attenuating calcium overload via reducing ryanodine receptor 2 activity
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.10.010
Abstract: Abstract Featured by heart dysfunction, the diabetic cardiomyopathy is causing mortality and morbidity in type 2 diabetes mellitus patients. Matrine was considered as a cardioprotective agent. This study was aimed to investigate the therapeutic effects… read more here.
Keywords: induced cardiac; ages induced; cardiac dysfunctions; ryr2 ... See more keywords
Curcumin against advanced glycation end products (AGEs) and AGEs-induced detrimental agents
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DOI: 10.1080/10408398.2017.1396200
Abstract: ABSTRACT Objectives: This study was aimed to review and collate effects of curcumin on generation of advanced glycation end products (AGEs) and AGEs induced detrimental agents.Methods: Pubmed, Googlescholar, ScienceDirect, and Scopus databases were searched. Searching… read more here.
Keywords: advanced glycation; ages induced; ages formation; review ... See more keywords
Etomidate ameliorated advanced glycation end-products (AGEs)-induced reduction of extracellular matrix genes expression in chondrocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1951926
Abstract: Osteoarthritis (OA) is a rheumatic disease common in the elderly. AGEs are the end products of glycation reactions and play an important role in the development of OA. Etomidate is a general anesthesia-inducing agent recently… read more here.
Keywords: ages induced; extracellular matrix; reduction extracellular; end products ... See more keywords
Sphingosine kinase 1 mediates AGEs-induced fibronectin upregulation in diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20205
Abstract: Activation of sphingosine kinase 1 (SphK1) signaling pathway mediates fibronectin (FN) upregulation in glomerular mesangial cells (GMCs) under high glucose (HG) condition. However, the roles of SphK1 in advanced glycation end products (AGEs)-induced DN have… read more here.
Keywords: fibronectin upregulation; sphingosine kinase; ages induced; sphk1 ... See more keywords
Protective Effect of Djulis (Chenopodium formosanum) Extract against UV- and AGEs-Induced Skin Aging via Alleviating Oxidative Stress and Collagen Degradation
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DOI: 10.3390/molecules27072332
Abstract: Skin aging is a complex process involving photoaging and glycation stress, which share some fundamental pathways and have common mediators. They can cause skin damage and collagen degradation by inducing oxidative stress and the accumulation… read more here.
Keywords: stress; ages induced; oxidative stress; collagen ... See more keywords