Astragaloside IV prevents memory impairment in D-galactose-induced aging rats via the AGEs/RAGE/ NF-κB axis.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of medical research"
DOI: 10.1016/j.arcmed.2021.05.005
Abstract: BACKGROUND We investigated the effects of astragaloside IV (AS-IV) on memory function in aging rats mimicked by D-galactose administration and explored the potential molecular mechanisms. METHODS Twenty-seven male rats were randomly divided into control group… read more here.
Keywords: ages rage; memory impairment; rage axis; galactose induced ... See more keywords
Loganin and catalpol exert cooperative ameliorating effects on podocyte apoptosis upon diabetic nephropathy by targeting AGEs-RAGE signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117653
Abstract: BACKGROUND/AIMS Rehmanniae Radix (RR) and Cornus officinalis (CO) are a typical herbal pair used to treat diabetic nephropathy (DN) in clinical practice. DN can be effectively treated by catalpol (Cat) and loganin (Log), the main… read more here.
Keywords: ages rage; targeting ages; log cat; apoptosis ... See more keywords
AGEs/RAGE-Related Neurodegeneration: daf-16 as a Mediator, Insulin as an Ameliorant, and C. elegans as an Expedient Research Model.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.6b00264
Abstract: Advanced glycation end-products (AGEs) are nonenzymatically glycated proteins, lipids, and nucleic acids. These compounds both originate exogenously and are formed endogenously, and they are associated, along with one of their receptors (RAGE), with a variety… read more here.
Keywords: insulin; daf; ages rage; neurodegeneration ... See more keywords
AGEs RAGE Pathways: Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Drug Research"
DOI: 10.1055/a-2008-7948
Abstract: Abstract Neurofibrillary tangles and plaques containing tau serve as the biological markers for Alzheimer disease (AD) and pathogenesis is widely believed to be driven by the production and deposition of the β-amyloid peptide (Aβ). The… read more here.
Keywords: disease; alzheimer disease; rage pathways; amyloid peptide ... See more keywords
AGEs/RAGE Promote Osteogenic Differentiation in Rat Bone Marrow-Derived Endothelial Progenitor Cells via MAPK Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Research"
DOI: 10.1155/2022/4067812
Abstract: Systemic vascular impairment is the most common complication of diabetes. Advanced glycation end products (AGEs) can exacerbate diabetes-related vascular damage by affecting the intima and media through a variety of mechanisms. In the study, we… read more here.
Keywords: differentiation; ages rage; age induced; rage ... See more keywords
1α,25-dihydroxyvitamin D3 promotes osseointegration of titanium implant via downregulating AGEs/RAGE pathway in T2DM
Sign Up to like & getrecommendations! Published in 2018 at "Endocrine Connections"
DOI: 10.1530/ec-18-0241
Abstract: Diabetes-induced advanced glycation end products (AGEs) overproduction would result in compromised osseointegration of titanium implant and high rate of implantation failure. 1α,25-dihydroxyvitamin D3 (1,25VD3) plays a vital role in osteogenesis, whereas its effects on the… read more here.
Keywords: 25vd3 could; titanium implant; ages rage; osseointegration titanium ... See more keywords
Mechanistic Study of Schisandra chinensis Fruit Mixture Based on Network Pharmacology, Molecular Docking and Experimental Validation to Improve the Inflammatory Response of DKD Through AGEs/RAGE Signaling Pathway
Sign Up to like & getrecommendations! Published in 2023 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s395512
Abstract: Background Diabetic kidney disease (DKD) is a major cause of end-stage renal disease (ESRD), and inflammation is the main causative mechanism. Schisandra chinensis fruit Mixture (SM) is an herbal formulation that has been used for… read more here.
Keywords: molecular docking; dkd; signaling pathway; pharmacology ... See more keywords
Combination of the Herbs Radix Rehmanniae and Cornus Officinalis Mitigated Testicular Damage From Diabetes Mellitus by Enhancing Glycolysis via the AGEs/RAGE/HIF-1α Axis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.678300
Abstract: Radix Rehmanniae and Cornus Officinalis (RR-CO) have been widely used as “nourishing Yin and tonifying kidney” herb pairs for the treatment of diabetes mellitus (DM) and its complications in traditional Chinese medicine (TCM). Based on… read more here.
Keywords: glycolysis; rage hif; ages rage; radix rehmanniae ... See more keywords
SMTP-44D Inhibits Atherosclerotic Plaque Formation in Apolipoprotein-E Null Mice Partly by Suppressing the AGEs-RAGE Axis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076505
Abstract: SMTP-44D has been reported to have anti-oxidative and anti-inflammatory reactions, including reduced expression of receptor for advanced glycation end products (RAGE) in experimental diabetic neuropathy. Although activation of RAGE with its ligands, and advanced glycation… read more here.
Keywords: atherosclerotic plaque; smtp 44d; mice; formation ... See more keywords
Virtual Screening of the Active Components of Garcinia mangostana Linn. Potentially Inhibiting the Interaction of Advanced Glycation End-products and their Receptor
Sign Up to like & getrecommendations! Published in 2020 at "Open Access Macedonian Journal of Medical Sciences"
DOI: 10.3889/oamjms.2020.5505
Abstract: BACKGROUND: Mangosteen (Garcinia mangostana L.) is a plant that contains various secondary metabolite compounds, one of which is xanthone. Xanthone in mangosteen has a variety of beneficial biological and medical effects, one of which is… read more here.
Keywords: active components; garcinia mangostana; ages rage; mangostin ... See more keywords