Aggregate-selective antibody attenuates seeded aggregation but not spontaneously evolving disease in SOD1 ALS model mice
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DOI: 10.1186/s40478-020-01032-2
Abstract: Increasing evidence suggests that propagation of the motor neuron disease amyotrophic lateral sclerosis (ALS) involves the pathogenic aggregation of disease-associated proteins that spread in a prion-like manner. We have identified two aggregate strains of human… read more here.
Keywords: seed; aggregation; disease; aggregate selective ... See more keywords