Structural Characterization of the Aggregates of Gemtuzumab Ozogamicin
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DOI: 10.1021/acsomega.8b03627
Abstract: The preparation of antibody drug conjugates (ADCs), particularly those containing hydrophobic payloads, may promote aggregate formation. The aggregate (high molecular mass species, HMMS) is an impurity that must be controlled in the final drug substance… read more here.
Keywords: preparation; structural characterization; gemtuzumab ozogamicin; characterization aggregates ... See more keywords