The degree of unsaturation of fatty acids in phosphatidylserine alters the rate of insulin aggregation and the structure and toxicity of amyloid aggregates
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14369
Abstract: Phosphatidylserine (PS) in the plasma membrane plays an important role in cell signaling and apoptosis. Cell degeneration is also linked to numerous amyloid diseases, pathologies that are associated with aggregation of misfolded proteins. In this… read more here.
Keywords: aggregation; toxicity; structure toxicity; unsaturation fatty ... See more keywords
SARS‐CoV‐2 spike protein aggregation is triggered by bacterial lipopolysaccharide
Sign Up to like & getrecommendations! Published in 2022 at "Febs Letters"
DOI: 10.1002/1873-3468.14490
Abstract: SARS‐CoV‐2 spike (S) protein is crucial for virus invasion in COVID‐19. Here, we showed that lipopolysaccharide (LPS) can trigger S protein aggregation at high doses of LPS and S protein. We demonstrated the formation of… read more here.
Keywords: aggregation; cov spike; protein aggregation; spike protein ... See more keywords
Understanding Mesoscale Aggregation of Shallow Cumulus Convection Using Large‐Eddy Simulation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Advances in Modeling Earth Systems"
DOI: 10.1002/2017ms000981
Abstract: Marine shallow cumulus convection, often mixed with thin stratocumulus, is commonly aggregated into mesoscale patches. The mechanism and conditions supporting this aggregation are elucidated using 36-hour large-eddy simulations (LES) on a 128 × 128 km… read more here.
Keywords: large eddy; aggregation; cumulus convection; shallow cumulus ... See more keywords
Surfactant-Stripped Micelles with Aggregation-Induced Enhanced Emission for Bimodal Gut Imaging In Vivo and Microbiota Tagging Ex Vivo.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202100356
Abstract: Aggregation-induced emission luminogens (AIEgens) hold promise for biomedical imaging and new approaches facilitating their aggregation state are desirable for fluorescence enhancement. Herein, a series of surfactant-stripped AIEgen micelles (SSAMs) with improved fluorescence are developed by… read more here.
Keywords: aggregation; fluorescence; surfactant stripped; aggregation induced ... See more keywords
From Nanoscopic to Macroscopic Materials by Stimuli‐Responsive Nanoparticle Aggregation
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202208995
Abstract: Stimuli‐responsive nanoparticle (NP) aggregation plays an increasingly important role in regulating NP assembly into microscopic superstructures, macroscopic 2D, and 3D functional materials. Diverse external stimuli are widely used to adjust the aggregation of responsive NPs,… read more here.
Keywords: aggregation; stimuli responsive; responsive nanoparticle; nanoscopic macroscopic ... See more keywords
Photocontrolled Light‐Harvesting Supramolecular Assembly Based on Aggregation‐Induced Excimer Emission
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Optical Materials"
DOI: 10.1002/adom.202001702
Abstract: Photocontrolled light‐harvesting supramolecular assembly with aggregation‐induced excimer emission is fabricated by polyanionic γ‐cyclodextrin (COONa‐γ‐CD), pyrene derivative (PYC12), Nile red (NiR), and diarylethene derivative (DAE) in aqueous solution. Benefiting from the COONa‐γ‐CD‐induced aggregation of PYC12, the… read more here.
Keywords: energy; emission; light harvesting; supramolecular assembly ... See more keywords
Reversible Cluster Aggregation and Growth Model for Graphene Suspensions
Sign Up to like & getrecommendations! Published in 2017 at "Aiche Journal"
DOI: 10.1002/aic.15962
Abstract: We present a reversible cluster aggregation model for 2-dimensional macromolecules represented by line segments in 2-dimensions; and, we use it to describe the aggregation process of functionalized graphene particles in an aqueous SDS surfactant solution.… read more here.
Keywords: cluster aggregation; aggregation; reversible cluster; graphene suspensions ... See more keywords
The antioxidant 2,3‐dichloro,5,8‐dihydroxy,1,4‐naphthoquinone inhibits acetyl‐cholinesterase activity and amyloid β42 aggregation: A dual target therapeutic candidate compound for the treatment of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1870
Abstract: Alzheimer's disease is characterized by amyloid β aggregation and cholinergic neurodegeneration. In the present study, pure DDN (2,3‐dichloro‐5,8‐dihydroxy‐1,4‐naphthoquinone) was examined, for the first time, for its dual potential as inhibitor of acetylcholinesterase (AChE) and Aβ42… read more here.
Keywords: aggregation; dichloro dihydroxy; dihydroxy naphthoquinone; alzheimer disease ... See more keywords
Importin α/β and the tug of war to keep TDP‐43 in solution: quo vadis?
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200181
Abstract: The transactivation response‐DNA binding protein of 43 kDa (TDP‐43) is an aggregation‐prone nucleic acid‐binding protein linked to the etiology of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). These conditions feature the accumulation of… read more here.
Keywords: tug war; aggregation; keep tdp; importin tug ... See more keywords
Aggregation kinetics of human mesenchymal stem cells under wave motion.
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology journal"
DOI: 10.1002/biot.201600448
Abstract: Human mesenchymal stem cells (hMSCs) are primary candidates in cell therapy and regenerative medicine but preserving their therapeutic potency following culture expansion is a significant challenge. hMSCs can spontaneously assemble into three-dimensional (3D) aggregates that… read more here.
Keywords: aggregation; human mesenchymal; motion; stem cells ... See more keywords
Inhibition of polyglutamine aggregation by SIMILAR huntingtin N‐terminal sequences: Prospective molecules for preclinical evaluation in Huntington's disease
Sign Up to like & getrecommendations! Published in 2017 at "Peptide Science"
DOI: 10.1002/bip.23021
Abstract: The mutant huntingtin protein (mHtt) fragments with expanded polyglutamine sequence forms microscopically visible aggregates in neurons, a hallmark of Huntington's disease (HD). The aggregation process and aggregates are possible targets of therapeutic intervention in HD.… read more here.
Keywords: huntingtin; aggregation; huntington disease; preclinical evaluation ... See more keywords