Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models
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DOI: 10.1021/acschemneuro.1c00707
Abstract: Alzheimer’s disease, the most common form of dementia, is characterized by the aggregation of amyloid beta protein (Aβ). The aggregation and toxicity of Aβ are strongly modulated by metal ions and phospholipidic membranes. In particular,… read more here.
Keywords: peptide; aggregation; aggregation amyloid; cu2 ... See more keywords
Lanosterol disrupts the aggregation of amyloid-β peptides.
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DOI: 10.1021/acschemneuro.9b00285
Abstract: Lanosterol, an amphipathic molecule, was discovered only very recently to effectively hinder the aggregation of the lens proteins and dissolve the extremely stable fibrillar aggregates in cataracts. Here, we combined computational and experimental approaches to… read more here.
Keywords: aggregation; peptide; lanosterol disrupts; aggregation amyloid ... See more keywords
Amyloid-β peptide 37, 38 and 40 individually and cooperatively inhibit amyloid-β 42 aggregation
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DOI: 10.1039/d1sc02990h
Abstract: The pathology of Alzheimer's disease is connected to the aggregation of β-amyloid (Aβ) peptide, which in vivo exists as a number of length-variants. Truncations and extensions are found at both the N- and C-termini, relative… read more here.
Keywords: amyloid peptide; individually cooperatively; peptide individually; aggregation ... See more keywords