Characterization of Human IgG1 Fc Region Stability and Aggregation Propensity
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2663
Abstract: Monoclonal therapeutic antibodies (MAb) are highly valued for their efficacy in treating ailments ranging from arthritis to cancer. Unrivaled specificity and infrequent adverse effects benefit patients in ways traditional small molecule therapeutics cannot. However, formation… read more here.
Keywords: aggregation propensity; stability; human igg1; region ... See more keywords
Aggregation Behavior of Structurally Similar Therapeutic Peptides Investigated by 1H NMR and All-Atom Molecular Dynamics Simulations
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00883
Abstract: Understanding of peptide aggregation propensity is an important aspect in pharmaceutical development of peptide drugs. In this work, methodologies based on all-atom molecular dynamics (AA-MD) simulations and 1H NMR (in neat H2O) were evaluated as… read more here.
Keywords: dynamics simulations; aggregation propensity; aggregation; molecular dynamics ... See more keywords
Computational investigation on the effects of H50Q and G51D mutations on the α-Synuclein aggregation propensity
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2017.1347060
Abstract: The aggregation of α-synuclein is linked directly to the histopathology of Parkinson’s disease (PD). However, several missense mutations present in the α-synuclein gene (SNCA) have been known to be associated with PD. Several studies have… read more here.
Keywords: synuclein aggregation; aggregation; mutations synuclein; h50q g51d ... See more keywords
Advances in the prediction of protein aggregation propensity.
Sign Up to like & getrecommendations! Published in 2017 at "Current medicinal chemistry"
DOI: 10.2174/0929867324666170705121754
Abstract: Protein aggregation into β-sheet-enriched insoluble assemblies is being found to be associated with an increasing number of debilitating human pathologies, such as Alzheimer's disease or type 2 diabetes, but also with premature aging. Furthermore, protein… read more here.
Keywords: aggregation propensity; aggregation; advances prediction; protein aggregation ... See more keywords