Kinetics and competing mechanisms of antibody aggregation via bulk and surface-mediated pathways.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2020.01.005
Abstract: Non-native protein aggregation is a long-standing obstacle in the biopharmaceutical industry. Proteins can aggregate through different mechanisms, depending on the solution and stress conditions. Aggregation in bulk solution has been extensively studied in a mechanistic… read more here.
Keywords: surface mediated; aggregation; temperature; bulk surface ... See more keywords
Computational Design To Reduce Conformational Flexibility and Aggregation Rates of an Antibody Fab Fragment.
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DOI: 10.1021/acs.molpharmaceut.8b00186
Abstract: Computationally guided semirational design has significant potential for improving the aggregation kinetics of protein biopharmaceuticals. While improvement in the global conformational stability can stabilize proteins to aggregation under some conditions, previous studies suggest that such… read more here.
Keywords: protein; aggregation; design; aggregation kinetics ... See more keywords