Molecular crowding accelerates aggregation of α-synuclein by altering its folding pathway
Sign Up to like & getrecommendations! Published in 2021 at "European Biophysics Journal"
DOI: 10.1007/s00249-020-01486-1
Abstract: Intracellular macromolecular crowding can lead to increased aggregation of proteins, especially those that lack a natively folded conformation. Crowding may also be mimicked by the addition of polymers like polyethylene glycol (PEG) in vitro. α-Synuclein… read more here.
Keywords: aggregation; synuclein; aggregation synuclein; molecular crowding ... See more keywords
α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30808-9
Abstract: Aggregation of α-synuclein, the hallmark of α-synucleinopathies such as Parkinson’s disease, occurs in various glycosphingolipidoses. Although α-synuclein aggregation correlates with deficiencies in the lysosomal degradation of glycosphingolipids (GSL), the mechanism(s) involved in this aggregation remains… read more here.
Keywords: synuclein aggregation; aggregation; synuclein interacts; interacts directly ... See more keywords
The effect of mutant GBA1 on accumulation and aggregation of α-synuclein.
Sign Up to like & getrecommendations! Published in 2019 at "Human molecular genetics"
DOI: 10.1093/hmg/ddz005
Abstract: Gaucher disease (GD) patients and carriers of GD mutations have a higher propensity to develop Parkinson's disease (PD) in comparison to the non-GD population. This implies that mutant GBA1 allele is a predisposing factor for… read more here.
Keywords: accumulation aggregation; synuclein; mutant gcase; aggregation synuclein ... See more keywords
The Roles of ATP13A2 Gene Mutations Leading to Abnormal Aggregation of α-Synuclein in Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.927682
Abstract: Parkinson’s disease (PD) is the second most common neurodegenerative disease. PARK9 (also known as ATP13A2) is recognized as one of the key genes that cause PD, and a mutation in this gene was first discovered… read more here.
Keywords: atp13a2 gene; abnormal aggregation; disease; aggregation synuclein ... See more keywords