Chemometric modeling of the electrochemical data to investigate proline cis/trans isomeration effect on aggregation of Tau protein.
Sign Up to like & getrecommendations! Published in 2021 at "Protein expression and purification"
DOI: 10.1016/j.pep.2021.105858
Abstract: Tau protein (Tau) is a proline-rich protein and in this work, we have developed a very interesting strategy based on combination of electrochemistry with chemometric methods to investigate proline cis/trans isomeration effect on the Tau… read more here.
Keywords: protein; cis; aggregation; tau ... See more keywords
Electrostatically driven complex coacervation and amyloid aggregation of tau are independent processes with overlapping conditions.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00627
Abstract: Amyloid aggregation of the microtubule binding protein tau is a hallmark of many neurodegenerative diseases. Recently, tau has been found to undergo liquid-liquid phase separation (LLPS) by an electrostatically driven complex coacervation (CC) mechanism near… read more here.
Keywords: aggregation; tau; aggregation tau; electrostatically driven ... See more keywords