A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells.
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DOI: 10.1038/nchem.2754
Abstract: The self-propagation of misfolded conformations of tau underlies neurodegenerative diseases, including Alzheimer's. There is considerable interest in discovering the minimal sequence and active conformational nucleus that defines this self-propagating event. The microtubule-binding region, spanning residues… read more here.
Keywords: binding region; aggregation; microtubule binding; aggregation tau244 ... See more keywords