Vitamin K3 chloroderivative (VKT-2) inhibits HDAC6, activates autophagy and apoptosis and inhibits aggresome formation in hepatocellular carcinoma cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114176
Abstract: Epigenetics plays a vital role in regulating gene expression and determining the specific phenotypes of eukaryotic cells. Histone deacetylases (HDACs) are important epigenetic regulatory proteins effecting multiple biological functions. Particularly, HDAC6 has become a promising… read more here.
Keywords: vkt; huh; vkt inhibits; inhibits hdac6 ... See more keywords
Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.02.003
Abstract: Proteasome inhibitors have been shown to induce cell death in cancer cells by triggering an acute proteotoxic stress response characterized by accumulation of poly-ubiquitinated proteins, ER stress and the production of reactive oxygen species. The… read more here.
Keywords: proteasome inhibitor; inhibitor; ap15; proteotoxicity ... See more keywords
N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27872-6
Abstract: Accumulation of ubiquitinated protein aggregates is a common pathology associated with a number of neurodegenerative diseases and selective autophagy plays a critical role in their elimination. Although aging-related decreases in protein degradation properties may enhance… read more here.
Keywords: aggregation; p62; protein aggregation; formation without ... See more keywords
Autophagy Modulation in Aggresome Formation: Emerging Implications and Treatments of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10051027
Abstract: Alzheimer’s disease (AD) is one of the most prevailing neurodegenerative diseases in the world, which is characterized by memory dysfunction and the formation of tau and amyloid β (Aβ) aggregates in multiple brain regions, including… read more here.
Keywords: modulation aggresome; aggresome formation; alzheimer disease; autophagy modulation ... See more keywords
Transcriptional factor Nrf2 is essential for aggresome formation during proteasome inhibition
Sign Up to like & getrecommendations! Published in 2019 at "Biomedical Reports"
DOI: 10.3892/br.2019.1247
Abstract: Aggrephagy, the aggresome-related protein degradation system, represents a protective cellular response to shuttle misfolded proteins into the microtubule-organizing center for degradation through the autophagic pathway during stress conditions, including heat shock, oxidative stress and proteasome… read more here.
Keywords: factor nrf2; formation; proteasome inhibition; aggresome formation ... See more keywords