Integrated proteogenomic characterization of localized prostate cancer identifies biological insights and subtype-specific therapeutic strategies
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DOI: 10.1038/s41467-025-58569-w
Abstract: Localized prostate cancer (PCa) is highly variable in their response to therapies. Although a fraction of this heterogeneity can be explained by clinical factors or genomic and transcriptomic profiling, the proteomic-based profiling of aggressive PCa… read more here.
Keywords: localized prostate; prostate cancer; aggressive pca; prostate ... See more keywords
Characterisation of the main PSA glycoforms in aggressive prostate cancer
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DOI: 10.1038/s41598-020-75526-3
Abstract: Serum levels of prostate specific antigen (PSA) are commonly used for prostate cancer (PCa) detection. However, their lack of specificity to distinguish benign prostate pathologies from PCa, or indolent from aggressive PCa have prompted the… read more here.
Keywords: psa; aggressive pca; prostate cancer; pca ... See more keywords
Elucidation of the Genomic-Epigenomic Interaction Landscape of Aggressive Prostate Cancer
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DOI: 10.1155/2021/6641429
Abstract: Background Majority of prostate cancer (PCa) deaths are attributed to localized high-grade aggressive tumours which progress rapidly to metastatic disease. A critical unmet need in clinical management of PCa is discovery and characterization of the… read more here.
Keywords: aggressive pca; genomic epigenomic; prostate cancer; pca ... See more keywords