Association Between Combined TMPRSS2: ERG and PCA3 RNA Urinary Testing and Detection of Aggressive Prostate Cancer
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2017.0177
Abstract: Importance Potential survival benefits from treating aggressive (Gleason score, ≥7) early-stage prostate cancer are undermined by harms from unnecessary prostate biopsy and overdiagnosis of indolent disease. Objective To evaluate the a priori primary hypothesis that… read more here.
Keywords: prostate; biopsy; pca3; prostate cancer ... See more keywords
Methylation‐associated miR‐193b silencing activates master drivers of aggressive prostate cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12536
Abstract: Epigenetic silencing of miRNA is a primary mechanism of aberrant miRNA expression in cancer, and hypermethylation of miRNA promoters has been reported to contribute to prostate cancer initiation and progression. Recent data have shown that… read more here.
Keywords: methylation; prostate cancer; cancer; mir 193b ... See more keywords
Chromosome 5 harbors two independent deletion hotspots at 5q13 and 5q21 that characterize biologically different subsets of aggressive prostate cancer
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Cancer"
DOI: 10.1002/ijc.33344
Abstract: Deletion of chromosome 5q is common in prostate cancer and is linked to aggressive disease. Most previous studies focused on 5q21 where CHD1 is located, but deletion of mapping studies has identified a second deletion… read more here.
Keywords: aggressive prostate; deletion; prostate cancer; 5q13 5q21 ... See more keywords
Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.06.003
Abstract: Genome-wide association studies (GWAS) have identified rs11672691 at 19q13 associated with aggressive prostate cancer (PCa). Here, we independently confirmed the finding in a cohort of 2,738 PCa patients and discovered the biological mechanism underlying this association.… read more here.
Keywords: prostate cancer; pca; biology; aggressive prostate ... See more keywords
Immunoarray Measurements of Parathyroid Hormone-Related Peptides Combined with Other Biomarkers to Diagnose Aggressive Prostate Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c02648
Abstract: Parathyroid hormone-related peptide (PTHrP) is related to bone metastasis and hypercalcemia in prostate and breast cancers and should be an excellent biomarker for aggressive forms of these cancers. Current clinical detection protocols for PTHrP are… read more here.
Keywords: prostate cancer; prostate; parathyroid hormone; aggressive prostate ... See more keywords
Urinary PSA and Serum PSA for Aggressive Prostate Cancer Detection
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15030960
Abstract: Simple Summary Prostate cancer remains one of the leading causes of death in men in the United States. The commonly utilized method of diagnosing prostate cancer is via the digital rectal examination and serum PSA… read more here.
Keywords: prostate cancer; serum; prostate; psa ... See more keywords
Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14163306
Abstract: Three metabolite patterns have previously shown prospective inverse associations with the risk of aggressive prostate cancer within the European Prospective Investigation into Cancer and Nutrition (EPIC). Here, we investigated dietary and lifestyle correlates of these… read more here.
Keywords: aggressive prostate; prostate cancer; cancer; metabolite patterns ... See more keywords