Aging and age‐related diseases: from mechanisms to therapeutic strategies
Sign Up to like & getrecommendations! Published in 2021 at "Biogerontology"
DOI: 10.1007/s10522-021-09910-5
Abstract: Aging is a physiological process mediated by numerous biological and genetic pathways, which are directly linked to lifespan and are a driving force for all age-related diseases. Human life expectancy has greatly increased in the… read more here.
Keywords: diseases mechanisms; mechanisms therapeutic; aging age; age related ... See more keywords
Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases
Sign Up to like & getrecommendations! Published in 2017 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2016.04.006
Abstract: As regulators of bioenergetics in the cell and the primary source of endogenous reactive oxygen species (ROS), dysfunctional mitochondria have been implicated for decades in the process of aging and age-related diseases. Mitochondrial DNA (mtDNA)… read more here.
Keywords: replication machinery; age related; aging age; dna ... See more keywords
Senescent B cells in aging and age-related diseases: Their role in the regulation of antibody responses
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2017.07.002
Abstract: ABSTRACT Immune cells with a senescence‐associated secretory phenotype increase in the blood of elderly individuals or individuals with age‐associated diseases or with infections. Although senescent immune cells do not proliferate, they are transcriptionally and metabolically… read more here.
Keywords: aging age; senescent cells; age; cells aging ... See more keywords
Contribution of proteases to the hallmarks of aging and to age‐related neurodegeneration
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13603
Abstract: Protein quality control ensures the degradation of damaged and misfolded proteins. Derangement of proteostasis is a primary cause of aging and age‐associated diseases. The ubiquitin–proteasome and autophagy‐lysosome play key roles in proteostasis but, in addition… read more here.
Keywords: age related; age; related neurodegeneration; aging age ... See more keywords
Xenotopic synthetic biology: Prospective tools for delaying aging and age-related diseases.
Sign Up to like & getrecommendations! Published in 2025 at "Science advances"
DOI: 10.1126/sciadv.adu1710
Abstract: Metabolic dysregulation represents one of the major driving forces in aging. Although multiple genetic and pharmacological manipulations are known to extend longevity in model organisms, aging is a complex trait, and targeting one's own genes… read more here.
Keywords: age; aging age; biology; xenotopic synthetic ... See more keywords
Abstract 13075: A Novel Senolytic Drug, Seno-7284 Ameliorates Aging and Age-related Cardiometabolic Disorders
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.13075
Abstract: Introduction: Recent studies have shown elimination of senescent cells, so-called "senolysis" has the potential to become a novel therapy for aging and age-related disorders. However, there is no s... read more here.
Keywords: abstract 13075; novel senolytic; age related; 13075 novel ... See more keywords
Endothelial Glycocalyx in Aging and Age-related Diseases.
Sign Up to like & getrecommendations! Published in 2023 at "Aging and disease"
DOI: 10.14336/ad.2023.0131
Abstract: The worldwide population is aging exponentially, creating burdens to patients, their families and society. Increasing age is associated with higher risk of a wide range of chronic diseases, and aging of the vascular system is… read more here.
Keywords: age related; aging age; related diseases; glycocalyx ... See more keywords
Reverse electron transfer is activated during aging and contributes to aging and age‐related disease
Sign Up to like & getrecommendations! Published in 2023 at "EMBO reports"
DOI: 10.15252/embr.202255548
Abstract: Mechanisms underlying the depletion of NAD+ and accumulation of reactive oxygen species (ROS) in aging and age‐related disorders remain poorly defined. We show that reverse electron transfer (RET) at mitochondrial complex I, which causes increased… read more here.
Keywords: age related; electron transfer; aging age; reverse electron ... See more keywords
Dysfunction and toxicity of damaged proteins in the etiology of aging and age-related degenerative and malignant diseases
Sign Up to like & getrecommendations! Published in 2020 at "Croatian Medical Journal"
DOI: 10.3325/cmj.2020.61.159
Abstract: Health can be defined as a harmony, or homeostasis, of the activities of thousands of different proteins, whereas aging and diseases result from their disharmony manifested at the levels of cells and tissues. Such disharmony… read more here.
Keywords: age related; aging age; etiology; related degenerative ... See more keywords
Regulation of Mitophagy by Sirtuin Family Proteins: A Vital Role in Aging and Age-Related Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.845330
Abstract: Sirtuins are protein factors that can delay aging and alleviate age-related diseases through multiple molecular pathways, mainly by promoting DNA damage repair, delaying telomere shortening, and mediating the longevity effect of caloric restriction. In the… read more here.
Keywords: age related; role aging; sirtuin family; aging age ... See more keywords
Effects and Mechanisms of Lutein on Aging and Age-Related Diseases
Sign Up to like & getrecommendations! Published in 2024 at "Antioxidants"
DOI: 10.3390/antiox13091114
Abstract: Aging and age-related diseases are serious public health issues that are receiving growing attention from researchers. Lutein has a critical function in the prevention and management of these issues. Possible mechanisms mainly include suppressing inflammation… read more here.
Keywords: age; aging age; effects mechanisms; related diseases ... See more keywords