An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance.
Sign Up to like & getrecommendations! Published in 2020 at "Cell metabolism"
DOI: 10.1016/j.cmet.2020.01.009
Abstract: It is well documented that the rate of aging can be slowed, but it remains unclear to which extent aging-associated conditions can be reversed. How the interface of immunity and metabolism impinges upon the diabetes… read more here.
Keywords: inflammation insulin; aging associated; inflammation; insulin resistance ... See more keywords
Further studies of the effects of aging on arginine metabolites in the rat vestibular nucleus and cerebellum
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.02.033
Abstract: Some studies have demonstrated that aging is associated with impaired vestibular reflexes, especially otolithic reflexes, resulting in postural instability. However, the neurochemical basis of these age-related changes is still poorly understood. The l-arginine metabolic system… read more here.
Keywords: arginine metabolites; vestibular nucleus; vnc; irrespective testing ... See more keywords
Aging is associated with maladaptive episodic memory-guided social decision-making
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208681119
Abstract: Significance Older adults are frequently targets of financial fraud. Therefore, understanding how cognitive changes across adulthood impact social decisions with economic stakes is critical. We investigated, in adults aged 18 to 92, how memory for… read more here.
Keywords: social decisions; associated maladaptive; older adults; aging associated ... See more keywords
New insights into aging-associated characteristics of female subcutaneous adipose tissue through integrative analysis of multi-omics data
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2020467
Abstract: ABSTRACT Aging could be critical in limiting the application of subcutaneous adipose tissue (SAT) in tissue repair and reconstruction. However, no systematic study on the characteristics of SAT aging has been conducted. In this study,… read more here.
Keywords: multi omics; subcutaneous adipose; aging associated; adipose tissue ... See more keywords
Aging differentially affects LTCC function in hippocampal CA1 and piriform cortex pyramidal neurons.
Sign Up to like & getrecommendations! Published in 2022 at "Cerebral cortex"
DOI: 10.1093/cercor/bhac152
Abstract: Aging is associated with cognitive decline and memory loss in humans. In rats, aging-associated neuronal excitability changes and impairments in learning have been extensively studied in the hippocampus. Here, we investigated the roles of L-type… read more here.
Keywords: ca1; adult; piriform cortex; aging associated ... See more keywords
Distinct dietary alpha-linolenic acid-dependent shifts in the fecal microbiome composition suppresses aging-associated inflammatory responses and thrombus formation
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.3773
Abstract: Aging is associated with alterations in the fecal microbiome composition. The microbiota-derived trimethylamine-N-oxide (TMAO) correlates with arterial thrombotic events, e.g. myocardial infarction and stroke, the leading causes of mortality worldwide. The omega-3 fatty acid (n-3… read more here.
Keywords: ala; thrombus formation; high ala; aging associated ... See more keywords
Identification of aging‐associated immunotypes and immune stability as indicators of post‐vaccination immune activation
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13703
Abstract: Immunosenescence describes immune dysfunction observed in older individuals. To identify individuals at‐risk for immune dysfunction, it is crucial to understand the diverse immune phenotypes and their intrinsic functional capabilities. We investigated immune cell subsets and… read more here.
Keywords: immune stability; aging associated; post vaccination; stability ... See more keywords
Aging is associated with a reduction in markers of mitochondrial energy metabolism in the human epidermis.
Sign Up to like & getrecommendations! Published in 2023 at "Experimental dermatology"
DOI: 10.1111/exd.14778
Abstract: The decline of mitochondrial function throughout the lifespan is directly linked to the development of aging phenotypes of the skin. Here, we assessed alterations in markers of epidermal mitochondrial energy metabolism as a function of… read more here.
Keywords: aging associated; epidermis; mitochondrial energy; energy metabolism ... See more keywords
Accelerated Epigenetic Aging Is Associated With Multiple Cardiometabolic, Hematologic, and Renal Abnormalities: A Project Baseline Health Substudy.
Sign Up to like & getrecommendations! Published in 2023 at "Circulation. Genomic and precision medicine"
DOI: 10.1161/circgen.122.003772
Abstract: BACKGROUND Epigenetic clocks estimate chronologic age using methylation levels at specific loci. We tested the hypothesis that accelerated epigenetic aging is associated with abnormal values in a range of clinical, imaging, and laboratory characteristics. METHODS… read more here.
Keywords: project baseline; accelerated epigenetic; epigenetic age; age ... See more keywords
Interplay Between Hereditary and Acquired Factors Determine Neutrophil Counts in Aging Individuals.
Sign Up to like & getrecommendations! Published in 2023 at "Blood advances"
DOI: 10.1182/bloodadvances.2022008793
Abstract: Blood cell production is complex, partly genetically determined and influenced by acquired factors. However, there is a paucity of data on how these factors interplay in the context of aging, which is associated with a… read more here.
Keywords: neutrophil counts; hereditary acquired; acquired factors; aging associated ... See more keywords
The Roles and Pharmacological Effects of FGF21 in Preventing Aging-Associated Metabolic Diseases
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.655575
Abstract: With the continuous improvement of living standards but the lack of exercise, aging-associated metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD) are becoming a lingering dark cloud… read more here.
Keywords: cellular aging; metabolism; metabolic diseases; fgf21 ... See more keywords