Pgk1 activation restores endothelial metabolic homeostasis to alleviate vascular aging and atherosclerosis
Sign Up to like & getrecommendations! Published in 2025 at "Cardiovascular Diabetology"
DOI: 10.1186/s12933-025-02976-2
Abstract: Terazosin (TZ), a well-known antagonist of the α1-adrenergic receptor (α1-AR), has demonstrated protective effects on vascular endothelial cells (ECs) and reduced vascular stiffness in clinical studies. Endothelial dysfunction and oxidative stress are central drivers of… read more here.
Keywords: atherosclerosis; pgk1; pgk1 activation; aging atherosclerosis ... See more keywords
Vascular Aging and Atherosclerosis: A Perspective on Aging
Sign Up to like & getrecommendations! Published in 2024 at "Aging and Disease"
DOI: 10.14336/ad.2024.0201-1
Abstract: Vascular aging (VA) is recognized as a pivotal factor in the development and progression of atherosclerosis (AS). Although various epidemiological and clinical research has demonstrated an intimate connection between aging and AS, the candidate mechanisms… read more here.
Keywords: atherosclerosis perspective; aging vascular; atherosclerosis; aging atherosclerosis ... See more keywords
The Complex Bidirectional Relationship Between Aging and Atherosclerosis: Mechanistic Insights and Translational Opportunities.
Sign Up to like & getrecommendations! Published in 2025 at "Aging and disease"
DOI: 10.14336/ad.2025.10620
Abstract: Aging is a major independent risk factor for atherosclerosis (AS), which in turn can accelerate systemic aging, thereby creating a self-reinforcing pathological cycle. These two processes share fundamental molecular mechanisms, such as endothelial dysfunction, phenotypic… read more here.
Keywords: bidirectional relationship; complex bidirectional; relationship aging; atherosclerosis ... See more keywords