Neuron–astrocyte signaling is preserved in the aging brain
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23112
Abstract: Astrocytes play crucial roles in brain homeostasis and are emerging as regulatory elements of neuronal and synaptic physiology by responding to neurotransmitters with Ca2+ elevations and releasing gliotransmitters that activate neuronal receptors. Aging involves neuronal… read more here.
Keywords: astrocyte neuron; physiology; brain; aging brain ... See more keywords
Neuroinflammaging and the Immune Landscape: The Role of Autophagy and Senescence in Aging Brain
Sign Up to like & getrecommendations! Published in 2025 at "Biogerontology"
DOI: 10.1007/s10522-025-10199-x
Abstract: Neuroinflammation is closely linked to aging, which damages the structure and function of the brain. It is caused by the intricate interactions of immune cells in the aged brain, such as the dysregulated glial cells… read more here.
Keywords: immune cells; brain; aging brain; autophagy senescence ... See more keywords
The structural–functional-connectivity coupling of the aging brain
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DOI: 10.1007/s11357-024-01106-2
Abstract: Aging primarily affects memory and executive functions, a relationship that may be underpinned by the fact that almost all adults over 60 years old develop small vessel disease (SVD). The fact that a wide range… read more here.
Keywords: connectivity coupling; network sfc; brain; aging brain ... See more keywords
Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration
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DOI: 10.1007/s13311-019-00742-3
Abstract: Lysosomes are acidic, membrane-bound organelles that serve as the primary catabolic compartment of the cell. They are crucial to a variety of cellular processes from nutrient storage to autophagy. Given the diversity of lysosomal functions,… read more here.
Keywords: preserving lysosomal; aging brain; function; lysosomal function ... See more keywords
Neurotherapeutics of the Aging Brain: Complexity Meets Complexity
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DOI: 10.1007/s13311-019-00757-w
Abstract: Both “aging” and the “brain” are vast topics that certainly merit study each in their own right, but when placed together, one seems hard put to know where to start. For many years, it has… read more here.
Keywords: sleep deprivation; aging brain; complexity; neurotherapeutics aging ... See more keywords
Sleep, Noninvasive Brain Stimulation, and the Aging Brain: Challenges and Opportunities
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DOI: 10.1016/j.arr.2020.101067
Abstract: As we age, sleep patterns undergo severe modifications of their micro and macrostructure, with an overall lighter and more fragmented sleep structure. In general, interventions targeting sleep represent an excellent opportunity not only to maintain… read more here.
Keywords: noninvasive brain; aging brain; stimulation; pathology ... See more keywords
Neurogenesis in the aging brain
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2017.06.116
Abstract: ABSTRACT Adult neurogenesis is the process of producing new neurons from neural stem cells (NSCs) for integration into the brain circuitry. Neurogenesis occurs throughout life in the ventricular‐subventricular zone (V‐SVZ) of the lateral ventricle and… read more here.
Keywords: aging brain; neurogenesis; pharmacology; neurogenesis aging ... See more keywords
Regulation of neurogenesis in the adult and aging brain
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2018.07.006
Abstract: Neural stem cells (NSCs) represent a remarkable developmental unit, necessary for the proper functioning of neurogenesis, by retaining their plasticity to self-renew and give rise to progeny throughout life in specific regions of the adult… read more here.
Keywords: adult aging; aging brain; neurogenesis; neurogenesis adult ... See more keywords
Harvard Aging Brain Study: Dataset and accessibility
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DOI: 10.1016/j.neuroimage.2015.03.069
Abstract: ABSTRACT The Harvard Aging Brain Study is sharing its data with the global research community. The longitudinal dataset consists of a 284‐subject cohort with the following modalities acquired: demographics, clinical assessment, comprehensive neuropsychological testing, clinical… read more here.
Keywords: harvard aging; brain study; aging brain; study ... See more keywords
Lasting consequences of concussion on the aging brain: Findings from the Baltimore Longitudinal Study of Aging
Sign Up to like & getrecommendations! Published in 2020 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2020.117182
Abstract: Studies suggest that concussions may be related to increased risk of neurodegenerative diseases, such as Chronic Traumatic Encephalopathy and Alzheimer’s Disease. Most neuroimaging studies show effects of concussionsin frontal and temporal lobes of the brain,… read more here.
Keywords: first imaging; aging brain; concussion; imaging visit ... See more keywords
Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive aging and brain injury
Sign Up to like & getrecommendations! Published in 2017 at "Progress in Neurobiology"
DOI: 10.1016/j.pneurobio.2015.12.008
Abstract: HIGHLIGHTSThe biological impacts of estrogen extend beyond the gonads to other bodily systems, including the brain and behavior.Conflicting preclinical and clinical data regarding actions of estrogens on the nervous system suggests that estrogen is a… read more here.
Keywords: aging brain; estrogen; cognitive aging; brain injury ... See more keywords