New directions in cancer and aging: State of the science and recommendations to improve the quality of evidence on the intersection of aging with cancer control
Sign Up to like & getrecommendations! Published in 2022 at "Cancer"
DOI: 10.1002/cncr.34143
Abstract: The global population of older cancer survivors is growing. However, the intersections of agingārelated health risks across the cancer control continuum are poorly understood, limiting the integration of aging into cancer control research and practice.… read more here.
Keywords: aging cancer; cancer control; improve quality; state science ... See more keywords
Mouse models in modeling aging and cancer
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2019.03.002
Abstract: ABSTRACT Mouse models have been widely used in the research of human diseases. Aging, just as cancer, is influenced by the interaction of various genetic and environmental factors. Currently, aging could be induced by many… read more here.
Keywords: cancer mouse; mouse models; modeling aging; cancer ... See more keywords
Aging and cancer epigenetics: Where do the paths fork?
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13709
Abstract: Aging and cancer are clearly associated processes, at both the epidemiological and molecular level. Epigenetic mechanisms are good candidates to explain the molecular links between the two phenomena, but recent reports have also revealed considerable… read more here.
Keywords: aging cancer; cell; paths fork; epigenetics paths ... See more keywords
Epigenetic clocks, aging, and cancer
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abn4009
Abstract: Description Global methylation changes in aging cells affect cancer risk and tissue homeostasis Cancer and aging are accompanied by stereotyped changes to the epigenetic landscape, including progressive loss of DNA methylation over gene-poor genomic regions… read more here.
Keywords: aging cancer; methylation; cancer; epigenetic clocks ... See more keywords
Abstract 1639: Telomere dynamics in aging and cancer by nanopore long-read sequencing
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-1639
Abstract: Telomeres are the protective, nucleoprotein structure at the ends of linear eukaryotic chromosomes. The accurate measurement of both telomeric length and composition of individual telomeres in mammalian cells has been challenged by the length and… read more here.
Keywords: cancer; read sequencing; long read; aging cancer ... See more keywords
A System-Level Investigation into the Mechanisms of Apigenin Against Inflammation
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DOI: 10.1177/1934578x19878600
Abstract: Apigenin is a natural flavone that possesses excellent biological activities especially against aging and cancer. However, the underlying mode of its action is not yet revealed. The purpose of this study was to examine the… read more here.
Keywords: system level; investigation mechanisms; mechanisms apigenin; level investigation ... See more keywords
Aging2Cancer: an integrated resource for linking aging to tumor multi-omics data
Sign Up to like & getrecommendations! Published in 2024 at "BMC Genomics"
DOI: 10.1186/s12864-024-11150-z
Abstract: Aging and tumorigenesis share intricate regulatory processes, that alter the genome, epigenome, transcriptome and immune landscape of tissues. Discovering the link between aging and cancer in terms of multiomics characteristics remains a challenge for biomedical… read more here.
Keywords: cancer; resource; linking aging; aging cancer ... See more keywords
Protein homeostasis in aging and cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1143532
Abstract: Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and… read more here.
Keywords: proteostasis; protein homeostasis; aging cancer; cancer ... See more keywords
Metformin Beyond Diabetes: A Precision Gerotherapeutic and Immunometabolic Adjuvant for Aging and Cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancers"
DOI: 10.3390/cancers17152466
Abstract: Simple Summary Metformin, originally developed for type 2 diabetes, is now being recognized for its broader potential in promoting healthy aging and enhancing cancer treatment. It affects several core biological pathways involved in aging, cancer… read more here.
Keywords: cancer; beyond diabetes; aging cancer; metformin ... See more keywords
Aging, Cancer, and Inflammation: The Telomerase Connection
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25158542
Abstract: Understanding the complex dynamics of telomere biology is important in the strong link between aging and cancer. Telomeres, the protective caps at the end of chromosomes, are central players in this connection. While their gradual… read more here.
Keywords: cancer; biology; telomerase; aging cancer ... See more keywords
Ī¤elomerase inhibitors and activators in aging and cancer: A systematic review
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2022.12674
Abstract: The main aim of the present systematic review was to summarize the most frequently used telomerase regulators with an impact on aging and cancer that are referred to in in vitro and in vivo studies.… read more here.
Keywords: aging cancer; telomerase; telomerase regulators; systematic review ... See more keywords