Cardiac aging and heart disease in humans
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Reviews"
DOI: 10.1007/s12551-017-0255-9
Abstract: The world population continues to grow older rapidly, mostly because of declining fertility and increasing longevity. Since age represents the largest risk factor for cardiovascular disease, the prevalence of these pathologies increases dramatically with increasing… read more here.
Keywords: cardiac aging; aging heart; age; heart disease ... See more keywords
Mechanosensing dysregulation in the fibroblast: A hallmark of the aging heart
Sign Up to like & getrecommendations! Published in 2020 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2020.101150
Abstract: The myofibroblast is a specialized fibroblast that expresses α-smooth muscle actin (α-SMA) and participates in wound contraction and fibrosis. The fibroblast to myofibroblast transition depends on chemical and mechanical signals. A fibroblast senses the changes… read more here.
Keywords: dysregulation fibroblast; fibroblast; aging heart; fibroblast hallmark ... See more keywords
Cardiovascular Aging and Heart Failure: JACC Review Topic of the Week.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2019.06.053
Abstract: Heart failure (HF) is a clinical syndrome that usually develops in the elderly. Complex interactions of the cardiovascular aging process with risk factors (obesity, hypertension, and atherosclerosis), comorbidities (anemia, chronic kidney disease, diabetes, and so… read more here.
Keywords: aging heart; review; heart failure; cardiovascular aging ... See more keywords
The Aging Heart: Mitophagy at the Center of Rejuvenation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2020.00018
Abstract: Aging is associated with structural and functional changes in the heart and is a major risk factor in developing cardiovascular disease. Many recent studies have focused on increasing our understanding of the basis of aging… read more here.
Keywords: heart; aging heart; mitophagy center; autophagy mitophagy ... See more keywords
The Role of Oxidative Stress in the Aging Heart
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DOI: 10.3390/antiox11020336
Abstract: Medical advances and the availability of diagnostic tools have considerably increased life expectancy and, consequently, the elderly segment of the world population. As age is a major risk factor in cardiovascular disease (CVD), it is… read more here.
Keywords: cardiac aging; oxidative stress; heart; role ... See more keywords
The Aging Heart: A Molecular and Clinical Challenge
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232416033
Abstract: Aging is associated with an increasing burden of morbidity, especially for cardiovascular diseases (CVDs). General cardiovascular risk factors, ischemic heart diseases, heart failure, arrhythmias, and cardiomyopathies present a significant prevalence in older people, and are… read more here.
Keywords: heart molecular; clinical challenge; aging heart; heart ... See more keywords