Imaging subtle leaks in the blood-brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions.
Sign Up to like & getrecommendations! Published in 2022 at "GeroScience"
DOI: 10.1007/s11357-022-00571-x
Abstract: Recent studies using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with gadolinium-based contrast agents (GBCA) have demonstrated subtle blood-brain barrier (BBB) leaks in the human brain during normal aging, in individuals with age-related cognitive dysfunction, genetic… read more here.
Keywords: brain barrier; aging human; human brain; blood brain ... See more keywords
Simulated microgravity accelerates aging of human skeletal muscle myoblasts at the single cell level.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.09.037
Abstract: Earth's gravity is essential for maintaining skeletal muscle mass and function in the body. The role of gravity in the myogenic mechanism has been studied with animal experiments in the International Space Station. Recently, gravity-control… read more here.
Keywords: skeletal muscle; muscle; simulated microgravity; aging human ... See more keywords
Aging of human alpha rhythm
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2018.05.018
Abstract: Alpha rhythm (AR) changes are the most pronounced electroencephalogram phenomenon in the aging brain. We analyzed them based on the inherent AR structure obtained by parallel factor analysis decomposition in the cortical source space. AR… read more here.
Keywords: aging human; age; alpha rhythm; component ... See more keywords
Chronological and biological aging of the human left ventricular myocardium: Analysis of microRNAs contribution
Sign Up to like & getrecommendations! Published in 2021 at "Aging Cell"
DOI: 10.1111/acel.13383
Abstract: Aging is the main risk factor for cardiovascular diseases. In humans, cardiac aging remains poorly characterized. Most studies are based on chronological age (CA) and disregard biological age (BA), the actual physiological age (result of… read more here.
Keywords: chronological biological; age; contribution; myocardium ... See more keywords
Epigenetic aging of human blood cells is influenced by the age of the host body
Sign Up to like & getrecommendations! Published in 2024 at "Aging Cell"
DOI: 10.1111/acel.14112
Abstract: Allogenic hematopoietic stem cell transplantation is a therapeutic procedure performed over a wide range of donor and recipient age combinations, representing natural experiments of how the age of the recipient affects aging in transplanted donor… read more here.
Keywords: age; epigenetic aging; human blood; blood cells ... See more keywords
Aging of the Human Lip: Current Knowledge and Clinical Implications
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cosmetic Dermatology"
DOI: 10.1111/jocd.70310
Abstract: Comprehensive exploration of lip aging remains limited due to anatomical complexity of the structure, with current investigations predominantly focusing on aspects such as dryness management, cheilitis prevention and treatment, and surgical lifts. read more here.
Keywords: clinical implications; lip current; current knowledge; knowledge clinical ... See more keywords
Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-18-1474
Abstract: Aging is associated with functional decline of hematopoietic stem cells (HSC) as well as an increased risk of myeloid malignancies. We performed an integrative characterization of epigenomic and transcriptomic changes, including single-cell RNA-seq, during normal… read more here.
Keywords: epigenetic reprogramming; aging human; stem cells; hematopoietic stem ... See more keywords
KNUST aging and human immunodeficiency virus outcomes—Study protocol
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DOI: 10.1371/journal.pone.0307719
Abstract: Introduction Globally, 7 million people with HIV (PWH) aged over 50 years exist. 5 million of them live in sub-Saharan Africa, the epicenter of the HIV epidemic. In Ghana, every 1 in 6 PWH is… read more here.
Keywords: hiv; pwh aged; aged years; aging human ... See more keywords
A Perfect Storm: The Convergence of Aging, Human Immunodeficiency Virus Infection, and Inflammasome Dysregulation
Sign Up to like & getrecommendations! Published in 2024 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb46050287
Abstract: The emergence of combination antiretroviral therapy (cART) has greatly transformed the life expectancy of people living with HIV (PWH). Today, over 76% of the individuals with HIV have access to this life-saving therapy. However, this… read more here.
Keywords: storm convergence; perfect storm; infection; human immunodeficiency ... See more keywords