Imaging subtle leaks in the blood-brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions.
Sign Up to like & getrecommendations! Published in 2022 at "GeroScience"
DOI: 10.1007/s11357-022-00571-x
Abstract: Recent studies using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with gadolinium-based contrast agents (GBCA) have demonstrated subtle blood-brain barrier (BBB) leaks in the human brain during normal aging, in individuals with age-related cognitive dysfunction, genetic… read more here.
Keywords: brain barrier; aging human; human brain; blood brain ... See more keywords
Simulated microgravity accelerates aging of human skeletal muscle myoblasts at the single cell level.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.09.037
Abstract: Earth's gravity is essential for maintaining skeletal muscle mass and function in the body. The role of gravity in the myogenic mechanism has been studied with animal experiments in the International Space Station. Recently, gravity-control… read more here.
Keywords: skeletal muscle; muscle; simulated microgravity; aging human ... See more keywords
Aging of human alpha rhythm
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2018.05.018
Abstract: Alpha rhythm (AR) changes are the most pronounced electroencephalogram phenomenon in the aging brain. We analyzed them based on the inherent AR structure obtained by parallel factor analysis decomposition in the cortical source space. AR… read more here.
Keywords: aging human; age; alpha rhythm; component ... See more keywords
Chronological and biological aging of the human left ventricular myocardium: Analysis of microRNAs contribution
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DOI: 10.1111/acel.13383
Abstract: Aging is the main risk factor for cardiovascular diseases. In humans, cardiac aging remains poorly characterized. Most studies are based on chronological age (CA) and disregard biological age (BA), the actual physiological age (result of… read more here.
Keywords: chronological biological; age; contribution; myocardium ... See more keywords
Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-18-1474
Abstract: Aging is associated with functional decline of hematopoietic stem cells (HSC) as well as an increased risk of myeloid malignancies. We performed an integrative characterization of epigenomic and transcriptomic changes, including single-cell RNA-seq, during normal… read more here.
Keywords: epigenetic reprogramming; aging human; stem cells; hematopoietic stem ... See more keywords