Aging and the immune system: An overview.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2018.08.005
Abstract: The world is witnessing a rapid demographic shift towards an older population, a trend with major medical, social, economic and political implications. Aging is a multifaceted process, involving numerous molecular and cellular mechanisms in the… read more here.
Keywords: aging immune; immune system; system overview; system ... See more keywords
Impact of aging on immune function in the pathogenesis of pulmonary diseases: Potential for therapeutic targets.
Sign Up to like & getrecommendations! Published in 2023 at "Expert review of respiratory medicine"
DOI: 10.1080/17476348.2023.2205127
Abstract: INTRODUCTION Several immunological alterations that occur during pulmonary diseases often mimic alterations observed in the aged lung. From the molecular perspective, pulmonary diseases and aging partake in familiar mechanisms associated with significant dysregulation of the… read more here.
Keywords: aging immune; pulmonary diseases; lung; immune function ... See more keywords
Aging and the immune response to organ transplantation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Investigation"
DOI: 10.1172/jci90601
Abstract: An increasing number of older people receive organ transplants for various end-stage conditions. Although organ transplantation is an effective therapy for older patients (i.e., older than 65 years of age), such as in end-stage renal… read more here.
Keywords: aging immune; response organ; organ transplantation; transplantation ... See more keywords
Premature aging of the immune system affects the response to SARS-CoV-2 mRNA vaccine in β-thalassemia: role of an additional dose
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2022017594
Abstract: Patients with β -thalassemia show 5-fold increase in age-standardized lethality due to SARS-CoV-2 infection, representing a high-risk population compared with age- and sex-matched healthy subjects. 1 Vaccination against SARS-CoV-2 is crucial to reduce mortality and… read more here.
Keywords: aging immune; cov mrna; vaccine; anti pf4 ... See more keywords
Protective Effects of Exercise Become Especially Important for the Aging Immune System in The Covid-19 Era
Sign Up to like & getrecommendations! Published in 2022 at "Aging and Disease"
DOI: 10.14336/ad.2021.1219
Abstract: Aging is a complex, multietiological process and a major risk factor for most non-genetic, chronic diseases including geriatric syndromes that negatively affect healthspan and longevity. In the scenario of “healthy or good aging”, especially during… read more here.
Keywords: system; aging immune; exercise; immune system ... See more keywords
Aging and an Immune Challenge Interact to Produce Prolonged, but Not Permanent, Reductions in Hippocampal L-LTP and mBDNF in a Rodent Model with Features of Delirium
Sign Up to like & getrecommendations! Published in 2018 at "eNeuro"
DOI: 10.1523/eneuro.0009-18.2018
Abstract: Abstract Aging increases the risk of abrupt declines in cognitive function after an event that triggers immune system activation (e.g. surgery, infection, or injury). This phenomenon is poorly understood, but rodent models may provide clues.… read more here.
Keywords: aging immune; immune challenge; rodent; ltp mbdnf ... See more keywords
The Neuroimmunology of Guillain-Barré Syndrome and the Potential Role of an Aging Immune System
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2020.613628
Abstract: Guillain-Barré syndrome (GBS) is a paralyzing autoimmune condition affecting the peripheral nervous system (PNS). Within GBS there are several variants affecting different aspects of the peripheral nerve. In general, there appears to be a role… read more here.
Keywords: aging immune; system; guillain barr; immune system ... See more keywords
A combined aging and immune prognostic signature predict prognosis and responsiveness to immunotherapy in melanoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.943944
Abstract: Background: Melanoma is the most lethal, and one of the most aggressive forms of cutaneous malignancies, which poor response to treatment has always puzzled clinicians. As is known to all, aging and immune microenvironment are… read more here.
Keywords: aging immune; prognosis; microenvironment; melanoma ... See more keywords
Molecular Markers of Blood Cell Populations Can Help Estimate Aging of the Immune System
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065708
Abstract: Aging of the immune system involves functional changes in individual cell populations, in hematopoietic tissues and at the systemic level. They are mediated by factors produced by circulating cells, niche cells, and at the systemic… read more here.
Keywords: system; aging immune; cell populations; age ... See more keywords