Alternative splicing in aging and longevity
Sign Up to like & getrecommendations! Published in 2019 at "Human Genetics"
DOI: 10.1007/s00439-019-02094-6
Abstract: Alternative pre-mRNA splicing increases the complexity of the proteome that can be generated from the available genomic coding sequences. Dysregulation of the splicing process has been implicated in a vast repertoire of diseases. However, splicing… read more here.
Keywords: longevity; splicing aging; aging longevity; rna splicing ... See more keywords
A short life on the farm: aging and longevity in agricultural, large-bodied mammals
Sign Up to like & getrecommendations! Published in 2020 at "GeroScience"
DOI: 10.1007/s11357-020-00190-4
Abstract: As average human lifespans increase across the globe, companion animals, specifically dogs and cats, are also living longer with more age-related morbidities. However, a similar trend is not seen in mammalian livestock species. Cows, pigs,… read more here.
Keywords: life farm; aging longevity; farm aging; longevity agricultural ... See more keywords
Host and microbiota metabolic signals in aging and longevity
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DOI: 10.1038/s41589-021-00837-z
Abstract: Aging is an inevitable biochemical process that adversely affects personal health and poses ever-increasing challenges to society. Recent research has revealed the crucial role of metabolism in regulating aging and longevity. During diverse metabolic processes,… read more here.
Keywords: longevity; host microbiota; metabolic signals; aging longevity ... See more keywords
Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience
Sign Up to like & getrecommendations! Published in 2020 at "Aging and Disease"
DOI: 10.14336/ad.2020.0603
Abstract: The interrelation of the processes of immunity and senescence now receives an unprecedented emphasis during the COVID-19 pandemic, which brings to the fore the critical need to combat immunosenescence and improve the immune function and… read more here.
Keywords: aging longevity; immunity; adaptive immunity; innate adaptive ... See more keywords
Circular RNA Involvement in Aging and Longevity
Sign Up to like & getrecommendations! Published in 2022 at "Current Genomics"
DOI: 10.2174/1389202923666220927110258
Abstract: Background Circular RNAs (circRNAs) are transcribed by RNA polymerase II and are mostly generated by the back-splicing of exons in the protein-coding gene. Massive circRNAs are reported to be differentially expressed in different species, implicating… read more here.
Keywords: involvement aging; longevity; circular rna; aging longevity ... See more keywords
Genetic Networks of Alzheimer’s Disease, Aging, and Longevity in Humans
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DOI: 10.3390/ijms24065178
Abstract: Human genomic analysis and genome-wide association studies (GWAS) have identified genes that are risk factors for early and late-onset Alzheimer's disease (AD genes). Although the genetics of aging and longevity has been extensively studied, previous… read more here.
Keywords: longevity; alzheimer disease; longevity genes; gene ... See more keywords
A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.34701
Abstract: Tumor suppressor p53 prevents early death due to cancer development. However, the role of p53 in aging process and longevity has not been well-established. In humans, single nucleotide polymorphism (SNP) with either arginine (R72) or… read more here.
Keywords: suppressor p53; tumor suppressor; aging longevity; p53 ... See more keywords