An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08831-9
Abstract: Aging promotes lung function decline and susceptibility to chronic lung diseases, which are the third leading cause of death worldwide. Here, we use single cell transcriptomics and mass spectrometry-based proteomics to quantify changes in cellular… read more here.
Keywords: single cell; cell transcriptomics; aging lung; atlas aging ... See more keywords
The Mechanobiology of Vascular Remodeling in the Aging Lung.
Sign Up to like & getrecommendations! Published in 2021 at "Physiology"
DOI: 10.1152/physiol.00019.2021
Abstract: Aging is accompanied by declining lung function and increasing susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by growing evidence, but underlying mechanisms remain elusive. In… read more here.
Keywords: mechanobiology vascular; physiology; vascular remodeling; remodeling aging ... See more keywords
Aging Lung: Molecular Drivers and Impact on Respiratory Diseases—A Narrative Clinical Review
Sign Up to like & getrecommendations! Published in 2024 at "Antioxidants"
DOI: 10.3390/antiox13121480
Abstract: The aging process significantly impacts lung physiology and is a major risk factor for chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), asthma, and non-IPF interstitial lung fibrosis. This narrative… read more here.
Keywords: clinical review; aging lung; respiratory diseases; lung ... See more keywords