Pim1 knockout alleviates sarcopenia in aging mice via reducing adipogenic differentiation of PDGFRα+ mesenchymal progenitors.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cachexia, sarcopenia and muscle"
DOI: 10.1002/jcsm.12770
Abstract: BACKGROUND Sarcopenia widely exists in elderly people and triggers numerous age-related events. The essential pathologic change lies in the increased intramuscular adipose tissue after aging with no exception to non-obese objects. Pim1 appears to be… read more here.
Keywords: mesenchymal progenitors; aging mice; adipogenic differentiation; pdgfr mesenchymal ... See more keywords
Activation of the miR-34a-Mediated SIRT1/mTOR Signaling Pathway by Urolithin A Attenuates d-Galactose-Induced Brain Aging in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Neurotherapeutics"
DOI: 10.1007/s13311-019-00753-0
Abstract: Despite tremendous advances in modern medicine, effective prevention or therapeutic strategies for age-related neurodegenerative diseases such as Alzheimer’s disease (AD) remain limited. Currently, accumulating evidence has demonstrated that microRNAs (miRNAs) are increasingly associated with age-related… read more here.
Keywords: induced brain; aging mice; mir 34a; signaling pathway ... See more keywords
Potential anti-aging effects of fermented wheat germ in aging mice
Sign Up to like & getrecommendations! Published in 2021 at "Food bioscience"
DOI: 10.1016/j.fbio.2021.101182
Abstract: Abstract Fermented wheat germ (FWG) is a valuable food ingredient and is naturally rich in antioxidant components; fermentation can improve the antioxidant capacity of wheat germ. The complex anti-aging effect of WG is not fully… read more here.
Keywords: wheat germ; mice; fermented wheat; aging mice ... See more keywords
BaZiBuShen alleviates altered testicular morphology and spermatogenesis and modulates Sirt6/P53 and Sirt6/NF-κB pathways in aging mice induced by D-galactose and NaNO2.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.113810
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Sperm infertility and testicular atrophy are symptoms associated with aging. BaZiBuShen formula (BZBS), a patented Chinese herbal prescription composed of Semen Cuscutae, Fructus Lycii, Epimedii Folium, Fructus Schisandrae Sphenantherae, Fructus Cnidii, Fructus Rosae… read more here.
Keywords: aging mice; bzbs; sirt6; sirt6 p53 ... See more keywords
Nrf2 knockout dysregulates iron metabolism and increases the hemolysis through ROS in aging mice.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117838
Abstract: AIMS Dysregulation of iron homeostasis in the body causes a variety of diseases. Iron deficiency leads to anemia, whereas iron overload aggravates cellular oxidative stress. Nuclear factor erythroid-2-related factor 2 (Nrf2) is a protein that… read more here.
Keywords: iron metabolism; aging mice; nrf2 mice; mice ... See more keywords
Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM
Sign Up to like & getrecommendations! Published in 2018 at "Neuron"
DOI: 10.1016/j.neuron.2018.09.010
Abstract: Although many reports have revealed dysfunction of endothelial cells in aging, resulting in blood-brain barrier (BBB) breakdown, the underlying mechanism or mechanisms remain to be explored. Here, we find that acid sphingomyelinase (ASM) is a critical… read more here.
Keywords: asm; aging mice; rejuvenation aging; neurogenic rejuvenation ... See more keywords
5-Heptadecylresorcinol Regulates the Metabolism of Thermogenic Fat and Improves the Thermogenic Capacity of Aging Mice via a Sirtuin 3-Adenosine Monophosphate-Activated Protein Kinase Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c07073
Abstract: 5-Heptadecylresorcinol (AR-C17), a well-known biomarker for whole grain rye consumption, is a primary homolog of alkylresorcinols. In this study, the effects of AR-C17 on the thermogenesis of brown adipocytes and 3T3-L1 adipocytes were investigated. The… read more here.
Keywords: c17 increased; adenosine monophosphate; thermogenic capacity; c17 ... See more keywords
Somatosensory innervation of the oral mucosa of adult and aging mice
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-28195-2
Abstract: Oral mechanoreception is implicated in fundamental functions including speech, food intake and swallowing; yet, the neuroanatomical substrates that encode mechanical stimuli are not well understood. Tactile perception is initiated by intricate mechanosensitive machinery involving dedicated… read more here.
Keywords: innervation oral; adult aging; aging mice; oral mucosa ... See more keywords
Effect of intranasal administration of neurotrophic factors on regeneration of chemically degenerated olfactory epithelium in aging mice
Sign Up to like & getrecommendations! Published in 2018 at "Neuroreport"
DOI: 10.1097/wnr.0000000000001125
Abstract: In the mammalian olfactory epithelium (OE), neurogenesis continues throughout the lifetime, by replacing olfactory receptor neurons (ORNs) lost by normal turnover in the postnatal period. However, this ability decreases with age and/or because of various… read more here.
Keywords: administration; intranasal administration; aging mice; growth factor ... See more keywords
Effect of clove on improving running ability in aging mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.14339
Abstract: In this study, a D-galactose-induced aging mouse model was established, and Syringa oblata Lindl. extract (SOLE) was administered orally to observe the effect and mechanism of SOLE on the running ability of aging mice. The… read more here.
Keywords: ability; effect; ability aging; aging mice ... See more keywords
Premature aging in mice with error-prone protein synthesis
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abl9051
Abstract: The main source of error in gene expression is messenger RNA decoding by the ribosome. Translational accuracy has been suggested on a purely correlative basis to positively coincide with maximum possible life span among different… read more here.
Keywords: life span; mice error; error prone; aging mice ... See more keywords